State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Five new limonoids, granaxylocarpins A-E (1-5), were isolated from the seeds of the Chinese marine mangrove Xylocarpus granatum. Granaxylocarpins A (1) and B (2) are mexicanolide-type limonoids with a 9,10-seco skeleton, and granaxylocarpin C (3) possesses an 8alpha,30alpha-epoxy ring and a rare 1,29-oxygen bridge. The structures of these limonoids were characterized on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis performed on 4. The structure of xyloccensin U (4a) was revised as 4b by comparison with granaxylocarpin D (4). The cytotoxicity of these isolates was evaluated against the P-388 and A-549 tumor cell lines.
"Among these, 406 were new structures, and 32 possessed previously unknown skeletons. A variety of assays revealed that 50 additional compounds had important biological activities31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71. Our research results supported the traditional medical applications of several plants in the Meliaceae family. "
[Show abstract][Hide abstract] ABSTRACT: This review describes the major discoveries of structurally diverse and/or biologically significant compounds from plant resources in China, mainly from the traditional Chinese medicines (TCMs) since the establishment of our research group in 1999. In the past decade, a large array of biologically significant and novel structures has been identified from plant resources (or TCM) in our laboratory. The structural modification of several biologically important compounds led to more than 400 derivatives, some of which exhibited significantly improved activities and provided opportunities to elucidate the structure-activity relationship of the related compound class. These findings are important for drug discovery and help us understand the biological basis for the traditional applications of these plants in TCM.
[Show abstract][Hide abstract] ABSTRACT: Seven new limonoids, amotsangins A-G (1-7), two known limonoids, and four known sesquiterpenoids were isolated from the twigs and leaves of Amoora tsangii. Their structures were elucidated primarily on the basis of spectroscopic data.
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