Safety and Efficacy of TIPS in Patients with Hemophilia and Cirrhosis

Department of Medicine, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143-0628, USA.
Journal of Vascular and Interventional Radiology (Impact Factor: 2.41). 03/2007; 18(2):309-12. DOI: 10.1016/j.jvir.2006.12.731
Source: PubMed


The prevalence of portal hypertension and its complications is increasing among patients with hemophilia and cirrhosis. The authors evaluated the safety and efficacy of transjugular intrahepatic postosystemic shunt (TIPS) placement in this population. A retrospective analysis was performed of adult patients who underwent TIPS placement at a single center. Four patients with hemophilia and cirrhosis were identified. Outcome measures included technical success and complications, recurrent gastrointestinal hemorrhage, shunt patency, hepatic encephalopathy, ascites control, and mortality. With periprocedural factor VIII supplementation, TIPS were placed in all patients without complications and with improvement in portal hypertension. Outcomes after TIPS placement appear to be comparable to those in patients without hemophilia.

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