Article

Role of cancer antigen-125 from pleural & ascitic fluid samples in non malignant conditions.

Department of Microbiology,Choithram Hospital & Research Centre, Indore, India.
The Indian journal of medical research (impact factor: 1.84). 01/2007; 125(1):25-30. pp.25-30
Source: PubMed

ABSTRACT CA-125, an ovarian tumor marker is known to increase in non malignant conditions such as tubercular and non tubercular pleuritis and ascites. We undertook this study to evaluate non-specific rise in CA-125 levels in conditions associated with pleural effusion and ascites and also to understand the mechanism of its secretion.
CA-125 levels in 38 pleural and 46 ascitic fluid samples from non malignant cases and 10 blood samples from pulmonary tuberculosis cases were estimated by ELISA. The ascitic fluid samples were collected from cases of bacterial peritonitis, tuberculosis, hepatitis, cirrhosis of other aetiology and pleural fluid samples were from cases of tubercular, pyogenic, cardiomegaly and other conditions.
Both ascitic and pleural fluid samples (transudative and exudative) showed elevated CA- 125 levels. The CA-125 levels were significantly higher in ascitic fluid samples than in pleural fluid samples.
Our findings showed that elevated levels of CA-125 in pleural and ascitic fluid could be because of varied aetiologies which need to be ruled out before considering malignancy. Peritoneum has a greater capacity to secrete CA-125 than the pleural epithelium and the secretion occurs following inflammation or mechanical distress. Pulmonary tuberculosis as a closed lesion without involvement of pleural epithelium does not evoke high CA-125 release.

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Keywords

10 blood samples
 
38 pleural
 
46 ascitic fluid samples
 
ascitic fluid
 
ascitic fluid samples
 
CA- 125 levels
 
CA-125 levels
 
closed lesion
 
elevated levels
 
non malignant cases
 
non malignant conditions
 
non tubercular pleuritis
 
non-specific rise
 
ovarian tumor marker
 
pleural epithelium
 
pleural fluid samples
 
Pulmonary tuberculosis
 
pulmonary tuberculosis cases
 
secrete CA-125
 
varied aetiologies
 

Yatiraj Kalantri