Characterizing the hoarding phenotype in individuals with OCD: associations with comorbidity, severity and gender.

Laboratory of Clinical Science, National Institute of Mental Health, USA.
Journal of Anxiety Disorders (Impact Factor: 2.96). 02/2008; 22(2):243-52. DOI: 10.1016/j.janxdis.2007.01.015
Source: PubMed

ABSTRACT Hoarding frequently occurs in obsessive-compulsive disorder (OCD), and some evidence suggests that it constitutes a distinct OCD subtype, with genetic contributions. This study investigated differences between OCD patients with and without hoarding symptoms. Of the 473 OCD patients studied, 24% were classified as hoarders according to combined interviewer and self-ratings, which were validated with the Savings Inventory-Revised in a subsample. Hoarders suffered from significantly more severe OCD symptoms, (especially compulsions) and had greater impairment and dysphoria. Hoarders also had more comorbid psychiatric disorders. Further study revealed that many of these differences were attributable to the female subjects: Compared to female non-hoarders, female hoarders were more likely to suffer from bipolar I, substance abuse, panic disorder, binge-eating disorder, and had greater OCD severity. Male hoarders had an increased prevalence of social phobia compared to non-hoarding males. These results suggest that there are gender-specific differences in the hoarding sub-phenotype of OCD.

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    ABSTRACT: [Correction Notice: An Erratum for this article was reported in Vol 18(1) of Review of General Psychology (see record 2014-20691-006). The affiliation and name of author Jenna G. Andrews of Morehouse College were incorrectly listed in the byline and author note as Jennifer G. Andrews-McClymont of Stephens College. The online version of this article has been corrected.] Recently, researchers have begun to advocate use of an animal model for understanding compulsive hoarding in humans. Nevertheless, a comprehensive review of the literature for this argument is lacking. We compare data for compulsive hoarding behavior in humans with hoarding in several vertebrates (rat, bird, and primate) to examine the potential validity of an animal model of hoarding. Although the strength of each animal model varies, there is provisional evidence in support of an analogue between hoarding in nonhuman animals (especially rodents) and humans, most notably on neurobiological grounds. Nevertheless, substantially more evidence is needed before this relationship can be confirmed with confidence. We identify gaps in the literature and offer suggestions for further investigation of the validity of animal models of human hoarding. (PsycINFO Database Record (c) 2014 APA, all rights reserved)
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