Wicherts IS, van Schoor NM, Boeke AJ, et al. Vitamin D status predicts physical performance and its decline in older persons

VU University Amsterdam, Amsterdamo, North Holland, Netherlands
Journal of Clinical Endocrinology &amp Metabolism (Impact Factor: 6.31). 07/2007; 92(6):2058-65. DOI: 10.1210/jc.2006-1525
Source: PubMed

ABSTRACT Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness.
The aim of this study was to investigate the association of serum 25-hydroxyvitamin D (25-OHD) concentration with current physical performance and its decline over 3 yr among elderly.
The study consisted of a cross-sectional and longitudinal design (3-yr follow-up) within the Longitudinal Aging Study Amsterdam.
An age- and sex-stratified random sample of the Dutch older population was used.
Subjects included 1234 men and women (aged 65 yr and older) for cross-sectional analysis and 979 (79%) persons for longitudinal analysis.
Physical performance (sum score of the walking test, chair stands, and tandem stand) and decline in physical performance were measured.
Serum 25-OHD was associated with physical performance after adjustment for age, gender, chronic diseases, degree of urbanization, body mass index, and alcohol consumption. Compared with individuals with serum 25-OHD levels above 30 ng/ml, physical performance was poorer in participants with serum 25-OHD less than 10 ng/ml [regression coefficient (B) = -1.69; 95% confidence interval (CI) = -2.28; -1.10], and with serum 25-OHD of 10-20 ng/ml (B = -0.46; 95% CI = -0.90; -0.03). After adjustment for confounding variables, participants with 25-OHD less than 10 ng/ml and 25-OHD between 10 and 20 ng/ml had significantly higher odds ratios (OR) for 3-yr decline in physical performance (OR = 2.21; 95% CI = 1.00-4.87; and OR = 2.01; 95% CI = 1.06-3.81), compared with participants with 25-OHD of at least 30 ng/ml. The results were consistent for each individual performance test.
Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.

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Available from: Arent Joan Boeke, Aug 24, 2015
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    • "It should be emphasised that 25(OH)D3 levels may significantly affect exercise capabilities of athletes. Multiple studies have shown a considerable correlation of vitamin D levels with muscle structure and strength (Wicherts et al., 2007; Mowe et al., 1999; Houston et al., 2007; Bischoff - Ferrari et al., 2004b; Bischoff et al., 1999). Visser et al. (2003) found that a 25(OH)D3 level of 30 ng/ml guarantees optimal muscle function. "
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    • " also for muscle . Bischoff et al . ( Bischoff et al . 2001 ; Bischoff - Ferrari et al . 2004 ) pointed out that the expression of the VDR in human skeletal muscle tissue decreases with age , and several studies have demonstrated that serum 25 ( OH ) Vit D is related to physical performance ( including walking test , chair stand and tandem stand ; Wicherts et al . 2007 ) and its rate of decline , body sway , and lower body strength ( Pfeifer et al . 2000 ) . In a recent meta - analysis , Vit D status was significantly associated with falls ( Bischoff - Ferrari et al . 2009 ) . Notably , 25 - OH Vit D is heritable ( h 2 =53% ; Livshits et al . 2003 ; Wang et al . 2010 ) ."
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    • "Muscular weakness is seen in association with vitamin D deficiency (Eriksen & Glerup, 2002; Perez-Lopez, 2007); vitamin D metabolite levels are predictive of physical performance in older people (Wicherts et al., 2007). Hypovitaminosis D correlates with increased postural sway and falls (Pfeifer et al., 2001). "
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