Increased QT interval variability index in acute alcohol withdrawal

Department of Psychiatry, Friedrich-Schiller-University, Philosophenweg 3, 07743 Jena, Germany.
Drug and Alcohol Dependence (Impact Factor: 3.42). 08/2007; 89(2-3):259-66. DOI: 10.1016/j.drugalcdep.2007.01.010
Source: PubMed


Acute alcohol withdrawal is associated with increased cardiovascular mortality, most likely due to cardiac arrhythmias. As the QT interval reflects the most critical phase for the generation of reentry and thus for arrhythmia, we examined QT variability in patients suffering from acute alcohol withdrawal.
High resolution electrocardiographic recordings were performed in 18 male unmedicated patients suffering from acute alcohol withdrawal, 18 matched controls and 15 abstained alcoholics. From these, parameters of beat-to-beat heart rate and QT variability such as approximate entropy and QT variability index (QTvi) were calculated. Measures were correlated with the severity of withdrawal symptoms and with serum electrolyte concentrations.
Heart rate and QTvi were significantly increased in acute alcohol withdrawal. Abstained alcoholics did not significantly differ from controls. While QTvi correlated with the severity of alcohol withdrawal symptoms, the mean QT interval duration showed an inverse relationship with serum potassium concentrations.
Our data indicate increased QT variability and thus increased repolarization lability in acute alcohol withdrawal. This might add to the elevated risk for serious cardiac arrhythmias. In part, these changes might be related to increased cardiac sympathetic activity or low potassium, thus suggesting the latter as possible targets for adjuvant pharmacological therapy during withdrawal.

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    • "Propofol's ability to mediate the hemodynamic instability during alcohol withdrawal is paramount in patients refractory to BZ treatment and should be started promptly when recognized. There is documented variability of QT intervals and ST segment changes associated with withdrawals as well as increases in myocardial oxygen demand secondary to a catecholamine surge [10, 11]. QT variability can lead to re-entry tachycardia and is arrhythmogenic, especially with the electrolyte imbalance most alcoholics possess. "
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    08/2014; 2014:638493. DOI:10.1155/2014/638493
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    • "In a case control study of human subjects Bar et al. have demonstrated that the QT interval is significantly prolonged in patients in acute alcohol withdrawal increasing the repolarization vulnerability of the myocardium. Authors assume that this prolongation is related to the sympathetic over activity during withdrawal [10]. The phenomenon of QT interval prolongation during alcohol withdrawal has also been investigated by Cuculi et al. [11]. "
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    ABSTRACT: ñ The article presents a review of current research on the influence of substitution drugs (LAAM, methadone, buprenorphine) on heart muscle repolarization (QTc prolongation). Results show that LAAM can cause QTc prolongation and increase the risk of tachyarrythmia (torsade de pointes ñ TdP), which may lead to severe symptoms such as collapse or even to sudden death. That was presented as a reason to withdraw LAAM from the pharmaceutical market. Consequently, interest about potentially similar effects of methadone on heart muscle repolariza- tion arose. It was confirmed that methadone may potentially cause QTc prolongation and lead to TdP. More specifically the following risk factors of QTc prolongation in methadone patients are observed: high methadone dose, high methadone plasma concentration, drugs pharmacokinetically interacting with methadone (CYP3A4), HIV infection, hypokalemia, liver cirrhosis, kidney insufficiency, and alco- hol withdrawal. Some authors put emphasis on a synergism of risk factors. In order to avoid severe circulation side effects (QT prolongation, TdP) the following recommenda- tions are forwarded: ECG assessment before admission to methadone substitution therapy, monitor- ing of ECG during treatment with methadone, avoidance of drugs that can interact with methadone. When QT prolongation appears methadone dose should be decreased.
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