The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Nature Structural & Molecular Biology (Impact Factor: 11.63). 05/2007; 14(4):341-3. DOI: 10.1038/nsmb1216
Source: PubMed

ABSTRACT Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.

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