Article

SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.

Laboratory of Bacteriology, Institut Pasteur Hellenique, Vas. Sofias 127, Athens 11521, Greece.
Antimicrobial Agents and Chemotherapy (impact factor: 4.84). 07/2007; 51(6):2185-8. DOI:10.1128/AAC.01439-06 pp.2185-8
Source: PubMed

ABSTRACT A novel class A beta-lactamase (SCO-1) encoded by an 80-kb self-transferable plasmid from Escherichia coli is described. The interaction of SCO-1 with beta-lactams was similar to that of the CARB-type enzymes. Also, SCO-1 exhibited a 51% amino acid sequence identity with the RTG subgroup of chromosomal carbenicillinases (RTG-1, CARB-5, and CARB-8).

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Keywords

51% amino acid sequence identity
 
beta-lactamase
 
CARB-type enzymes
 
chromosomal carbenicillinases
 
Escherichia coli
 
novel class