Imaging sequences for first pass perfusion - A review

Laboratory of Cardiac Energetics, Department of Health and Human Services, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1061, USA.
Journal of Cardiovascular Magnetic Resonance (Impact Factor: 5.11). 02/2007; 9(3):525-37. DOI: 10.1080/10976640601187604
Source: PubMed

ABSTRACT Myocardial perfusion imaging sequences and analysis techniques continue to improve. We review the state-of-the-art in cardiovascular magnetic resonance first pass perfusion pulse sequences including the application of parallel imaging. There are a wide range of sequence designs and parameters to consider when optimizing an acquisition protocol. The interdependence of these parameters forces the user to make compromises. We describe the technical issues and provide insights into the various performance tradeoffs. We also review the basic design for T1-weighted first pass myocardial perfusion imaging and go on to discuss the tradeoffs associated with various schemes to provide multi-slice coverage. Artifact mechanisms are discussed and related to sequence design and parameters. The selection of quantitative versus qualitative analysis affects various performance requirements, such as spatial and temporal resolution and linearity of enhancement. Understanding the interaction between the pulse sequence parameters and resulting image quality is important for improving myocardial perfusion imaging.

1 Follower
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We have evaluated the use of deconvolution using an exponential approximation basis for the quantification of myocardial blood flow from perfusion cardiovascular magnetic resonance. Our experiments, based on simulated signal intensity curves, phantom acquisitions, and clinical image data, indicate that exponential deconvolution allows for accurate quantification of myocardial blood flow. Together with automated respiratory motion correction myocardial contour delineation, the exponential deconvolution enables efficient and reproducible quantification of myocardial blood flow in clinical routine.
    IEEE transactions on bio-medical engineering 05/2012; 59(7):2060-7. DOI:10.1109/TBME.2012.2197620 · 2.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: PURPOSE: To develop and test the feasibility of a new method for non–ECG-gated first-pass perfusion (FPP) cardiac MR capable of imaging multiple short-axis slices at the same systolic cardiac phase. METHODS: A magnetization-driven pulse sequence was developed for non–ECG-gated FPP imaging without saturation-recovery preparation using continuous slice-interleaved radial sampling. The image reconstruction method, dubbed TRACE, used self-gating based on reconstruction of a real-time image-based navigator combined with reference-constrained compressed sensing. Data from ischemic animal studies (n=5) was used in a simulation framework to evaluate temporal fidelity. Healthy subjects (n=5) were studied using both the proposed and conventional method to compare the myocardial contrast-to-noise ratio (CNR). Patients (n=2) underwent adenosine stress studies using the proposed method. RESULTS: Temporal fidelity of the developed method was shown to be sufficient at high heart-rates. The healthy volunteers studies demonstrated normal perfusion and no artifacts. Compared with the conventional scheme, myocardial CNR for the proposed method was slightly higher (8.6 ± 0.6 versus 8.0 ± 0.7). Patient studies showed stress-induced perfusion defects consistent with invasive angiography. CONCLUSION: The presented methods and results demonstrate feasibility of the proposed approach for high-resolution non–ECG-gated FPP imaging and indicate its potential for achieving desirable image quality (high CNR, no dark-rim artifacts) with a 3-slice spatial coverage, all imaged at the same systolic phase. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc.
    Magnetic Resonance in Medicine 05/2015; DOI:10.1002/mrm.25752 · 3.40 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To demonstrate the feasibility of imaging the first passage of a bolus of hyperpolarized (13) C urea through the rodent heart using flow-sensitizing gradients to reduce signal from the blood pool. A flow-sensitizing bipolar gradient was optimized to reduce the bright signal within the cardiac chambers, enabling improved contrast of the agent within the tissue capillary bed. The gradient was incorporated into a dynamic golden angle spiral (13) C imaging sequence. Healthy rats were scanned during rest (n = 3) and under adenosine stress-induced hyperemia (n = 3). A two-fold increase in myocardial perfusion relative to rest was detected during adenosine stress-induced hyperemia, consistent with a myocardial perfusion reserve of two in rodents. The new pulse sequence was used to obtain dynamic images of the first passage of hyperpolarized (13) C urea in the rodent heart, without contamination from bright signal within the neighboring cardiac lumen. This probe of myocardial perfusion is expected to enable new hyperpolarized (13) C studies in which the cardiac metabolism/perfusion mismatch can be identified. Magn Reson Med, 2015. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
    Magnetic Resonance in Medicine 05/2015; DOI:10.1002/mrm.25713 · 3.40 Impact Factor


Available from