Fatal Pasteurella multocida septicemia and necrotizing fasciitis related with wound licked by a domestic dog
ABSTRACT A 68-y-old male had necrotizing fasciitis and bacteremia due to Pasteurella multocida. Saliva culture from his dog grew P. multocida and Pseudomonas aeruginosa. The human and dog P. multocida strains were of the same antibiogram but not identical tested with ribotyping. The wound licked by his dog was the only risk factor.
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ABSTRACT: To examine the variability among Pasteurella multocida strains isolated from pigs (nasal, tonsil and lung specimens) and humans in France. The genetic diversity of 117 French isolates of P. multocida, obtained from pigs (n = 101) and humans (n = 16) and three reference strains, was evaluated by pulsed-field gel electrophoresis (PFGE) after macrorestriction with ApaI. Sixty-four patterns were detected. The genetic relationships revealed five clusters (Aa1, Aa2, Aa3, Ab and B). The pig isolates obtained from pneumonic lungs and nasal cavities were clustered in groups Ab and Aa1, respectively (P < 0.05). Up to four different PFGE patterns were detected in the same farm. Isolates producing dermonecrotic toxins were clustered only in group Aa1, suggesting that the toxigenic isolates were more genetically homogenous than the others. Conversely, cluster Aa3 was significantly associated with human isolates even if the human isolates are spread over most of the clusters. Pasteurella multocida strains were genetically diverse, but pig and human isolates were significantly clustered in distinct phylogenetic groups. The discrimination index was >0.95 in both populations of human and pig isolates. Therefore, ApaI-PFGE seems to be a useful tool for epidemiological tracing of P. multocida infections.Journal of Applied Microbiology 06/2009; 107(6):1830-6. DOI:10.1111/j.1365-2672.2009.04360.x · 2.39 Impact Factor
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ABSTRACT: We present a case of fulminant Pasteurella multocida sepsis in a 66-year-old man who had undergone a renal transplant. Our patient lived with two dogs and a cat with which he was very close. We propose that his bacteraemia might have resulted from direct inoculation of P multocida via his cat licking the venous stasis ulcers on his legs. The patient's clinical course was complicated by cardiopulmonary failure and he ultimately succumbed to his infection. P multocida is a rare cause of infections in immunocompromised hosts, epidemiologically linked to exposure to cats, dogs, and other animals. This case of P multocida shows the importance of considering this organism in immunocompromised hosts presenting with severe infections, especially if their history shows exposure to domesticated or wild animals known to be potential carriers of this disease. In this Grand Round, we review the clinical features, epidemiology, treatment, and prognosis of P multocida infections with a focus on these features in patients who are immunosuppressed. Copyright © 2014 Elsevier Ltd. All rights reserved.The Lancet Infectious Diseases 11/2014; 15(2). DOI:10.1016/S1473-3099(14)70895-3 · 19.45 Impact Factor
Article: Microbiology of Animal Bites[Show abstract] [Hide abstract]
ABSTRACT: While animal interaction is largely a rewarding human endeavor, every year millions of people are bitten by animals, and most of these bites are inflicted by dogs and cats. While most of the bites do not require medical attention, some progress to a local soft tissue infection at the site of the injury. Like most cutaneous wound infections, the resultant infection is typically a polymicrobial mix consisting of common environmental organisms. However, a multitude of species-specific, soft tissue zoonoses are spread through animal bites. The pathogenic organisms may exist as normal salivary flora or may be present as part of a symptomatic or even asymptomatic infection in the animal. We concisely review the soft tissue infections caused by several species-specific pathogens transmitted through animal bites, with focus on dogs and cats, as they are by far the most commonly implicated species in human bite wounds.Clinical Microbiology Newsletter 04/2008; 30(7):47-50. DOI:10.1016/j.clinmicnews.2008.03.001