Congenital Melanocytic Nevus: An Epidemiologic Study in Italy

Azienda Ospedaliera G. Rummo, Benevento, Campania, Italy
Dermatology (Impact Factor: 1.57). 02/2007; 214(3):227-30. DOI: 10.1159/000099587
Source: PubMed


The prevalence of congenital melanocytic nevi (CMN) among newborns ranges between 0.2 and 6% in the worldwide literature. In the only available study from Italy the rate was 1% at birth and 1.4% at 2 years of age. Some surveys performed among samples of children and adolescents in other countries showed a prevalence which ranged from 1.4 to 4.4%. Additional data on the frequency in adults are not available.
The aim of this study was to estimate the prevalence of CMN in a large sample of a young male Italian population, which is deemed to be representative of the general population of the same age and sex.
The potential conscripts resident in the coastal regions of southern Italy, enlisted for the compulsory service in the Italian Navy, were called at the age of 18 to the Draft's Council Medical Unit of the Italian Navy in Taranto to evaluate their psychophysical fitness to recruitment. All the subjects examined from September 2002 to March 2004 showing skin lesions evocative of CMN were referred by general practitioners of the Draft's Council Medical Unit to the Department of Dermatology of the Italian Navy Hospital for confirming the diagnosis, which was based on the clinical features and the personal history. The confirmed cases were recorded in a predefined patient card, containing the main anamnestic and clinical data. Since the screening of small CMN in such a large sample of subjects was believed to be difficult, only CMN with a diameter >or=1.5 cm were recorded.
In 23,354 examined persons 157 CMN were diagnosed, with a prevalence of 0.67% (Bayesian 95% confidence interval 0.57-0.79); 126 (80.3%) CMN were medium-sized (>or=1.5 and <or=19.9 cm in diameter), and 31 (19.7%) were large (>or=20 cm in diameter). Three CMN (1.9%) were located on the face, 23 (14.6%) on the chest, 24 (15.2%) on the abdomen, 36 (22.9%) on the back, 48 (30.5%) on the lumbar area, 15 (9.5%) on the upper limb, 19 (12.1%) on the lower limb and 15 (9.5%) on the shoulder. No CMN was located on the head. In 19 cases (12.1%) >or=2 adjacent anatomical sites (shoulder/chest, shoulder/arm, etc.) were involved. In 73 moles (46.4%) terminal hairs were present. Eight CMN (5.1%) showed a zosteriform (i.e. segmental) feature. None of the examined subjects reported a personal history of malignant melanoma (MM), and no person with a history of MM was observed among all the enlisted men referred to the Department of Dermatology during the time of the study.
The prevalence of CMN in the Italian young male general population is roughly in agreement with the rates detected in general populations from other European studies. The observations of this study also suggest that the risk of appearance of MM, at least in childhood and adolescence, is limited for medium-sized CMN.

8 Reads
  • Source
    • "L'incidence des naevi congénitaux est d'un nouveau-né sur 20 000 et d'un nouveau-né sur 500 000 par an pour les naevi congénitaux géants (NCG) [1], avec une prédominance féminine (sex-ratio : 3/2) [2] [3]. Le caractère héréditaire des NCG n'a, à ce jour, pas été démontré [4]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The incidence of congenital nevi is one over 20,000 newborns per year, 14 % of them are located in the head and neck area. Nevi of the orbital region are particularly difficult to handle on the aesthetic and functional side. The objectives of this study were to conduct an analysis of different clinical presentations of congenital nevi of the eyelid orbital region in children to establish a treatment algorithm. We realised a bi-centric retrospective study including 51 children with orbito-palpebral congenital nevi. We analysed the different clinical presentations, their treatments and their results. Nineteen underwent direct suture excision; three a total skin graft; 15 a combination of treatments, among them four underwent tissular expansion and 14 patients were not operated and clinically followed-up. The average follow-up time was 6.6 years. In 33 cases residual nevic area was still present. The postoperative sequelae were: dyschromia (n=17), anatomical deformation of the eye (n=10), nevi outbreaks (n=8), internal canthus deformation (n=5) and ectropion (n=1). The results of our study show that therapeutic abstention is preferred when the aesthetic wrong is accepted by the patient and when there is not a higher risk of malignant degeneration. In order to minimise the risk of postoperative sequelae, we propose a therapeutic algorithm for the management of congenital orbital nevi. Copyright © 2014 Elsevier Masson SAS. All rights reserved.
  • Source
    • "L'incidence des naevi congénitaux est d'un nouveau-né sur 20 000 et d'un nouveau-né sur 500 000 par an pour les naevi congénitaux géants (NCG) [1], avec une prédominance féminine (sex-ratio : 3/2) [2] [3]. Le caractère héréditaire des NCG n'a, à ce jour, pas été démontré [4]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: L’incidence des naevi congénitaux est de un/20 000 nouveau-né par an, 14% des naevi congénitaux intéressent la région tête et cou. Les naevi de la région orbitaire sont particulièrement difficiles à prendre en charge sur le plan esthétique et fonctionnel.Les objectifs de cette étude étaient de réaliser une analyse des différentes présentations cliniques des naevi congénitaux de la région orbito-palpébrale chez l’enfant afin d’établir un algorithme thérapeutique.
    Annales de Chirurgie Plastique Esthétique 11/2014; DOI:10.1016/j.anplas.2014.11.004 · 0.31 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This article reviews congenital melanocytic nevi (CMN), which are present at birth or appear shortly thereafter, and their main histologic features. Several histologic variants and histopathologic criteria that differentiate CMN from other nevi, such as atypical or dysplastic nevi, and from nevoid malignant melanoma, are discussed. Histologic pitfalls in the correct identification of lentiginous melanocytic hyperplasia, pagetoid scatter, and proliferative nodules in the context of CMN are discussed. The risk for development of malignant melanoma in association with a congenital melanocytic nevus and variable causes for changing mole are discussed.
    Archives of Dermatology 08/1981; 117(7):379-80. · 4.79 Impact Factor
Show more