Strain-Dependent Variation in Mycobacterium bovis BCG-Induced Human T-Cell Activation and Gamma Interferon Production In Vitro

Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Infection and Immunity (Impact Factor: 3.73). 07/2007; 75(6):3197-201. DOI: 10.1128/IAI.01611-06
Source: PubMed


Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy
BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish
1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.

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Available from: Hazel M Dockrell, Oct 17, 2014
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    • "The importance of DCs in initiating an immune response against mycobacterial infections led us to investigate the activation induced on these APCs following stimulation with two widely employed and different BCG strains. The goal of the present study was to determine whether the strains divergences may influence their relative immunogenicity [12] [13], virulence [14] [15], and viability [16], factors that must be considered for the design and improvement of a vaccine against TB. We also analyzed the DCs' response to the commonly used MTB virulent laboratory strain (H37Rv) and to an MTB clinical isolate (CMT97), previously reported to behave differently from H37Rv in human macrophages [17], in order to understand if the laboratory strain could be considered a real model of DCs-MTB interaction. "
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