Article

[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension].

Department of Cardiology, Affiliated Yuhuangding Hospital, Qingdao University, Yantai, Shandong, 264000 PR China.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 04/2007; 24(2):153-6. pp.153-6
Source: PubMed

ABSTRACT To investigate whether the -344T/C polymorphism of aldosterone synthase gene is associated with early renal damage in Han nationality with essential hypertension in Shandong province.
Plasma aldosterone concentration and urinary albumin excretion were measured with radioimmunoassays in 225 patients with essential hypertension, and hypertensives were classified as hypertension with normal albuminuria or hypertension with microalbuminuria according to urinary albumin excretion during 24 hours. -344T/C polymorphism of aldosterone synthase gene was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in controls and hypertensives.
No significant differences were found in genotype distribution among groups of control, primary hypertension with normal albuminuria and hypertension with microalbuminuria. The C allele frequency in hypertension with microal buminuria group was significantly higher than that in control and hypertension with normal albuminuria group (P < 0.05). In hypertensive patients, plasma aldosterone concentration and urinary albumin excretion of TC+CC genotypes were significantly higher than that of TT genotype ( P< 0.05).
These results suggest that -344T/C polymorphism of aldosterone synthase gene may be associated with early renal damage in Han nationality with essential hypertension, C allele may be a genetic factor susceptible to renal damage in hypertensives.

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Keywords

-344T/C polymorphism
 
aldosterone synthase gene
 
C allele
 
C allele frequency
 
essential hypertension
 
genetic factor susceptible
 
genotype distribution
 
Han nationality
 
hypertensive patients
 
microal buminuria group
 
microalbuminuria
 
normal albuminuria
 
normal albuminuria group
 
plasma aldosterone concentration
 
polymerase chain reaction-restriction fragment length polymorphism
 
primary hypertension
 
Shandong province
 
TC+CC genotypes
 
TT genotype
 
urinary albumin excretion