The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty Liver Disease: A Pilot Study

Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract (CIRANAD), Unit of Gastroenterology, Second University of Naples, Naples, Italy.
Digestive Diseases and Sciences (Impact Factor: 2.61). 10/2007; 52(9):2387-95. DOI: 10.1007/s10620-006-9703-2
Source: PubMed


Oxidative stress leads to chronic liver damage. Silybin has been conjugated with vitamin E and phospholipids to improve its antioxidant activity. Eighty-five patients were divided into 2 groups: those affected by nonalcoholic fatty liver disease (group A) and those with HCV-related chronic hepatitis associated with nonalcoholic fatty liver disease (group B), nonresponders to treatment. The treatment consisted of silybin/vitamin E/phospholipids. After treatment, group A showed a significant reduction in ultrasonographic scores for liver steatosis. Liver enzyme levels, hyperinsulinemia, and indexes of liver fibrosis showed an improvement in treated individuals. A significant correlation among indexes of fibrosis, body mass index, insulinemia, plasma levels of transforming growth factor-beta, tumor necrosis factor-alpha, degree of steatosis, and gamma-glutamyl transpeptidase was observed. Our data suggest that silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage.

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Available from: Alessandro Federico, Oct 08, 2015
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    • "In these studies, it shows that extract of Milk Thistle (MT) reduced treatment period of acute and chronic hepatitis (Saller et al., 2007). Protective effects of Milk thistle in fatty liver, cirrhosis, viral hepatitis, ischemic liverdamage and cancer was shown previously (Loguercio et al., 2007). Buzzelli and colleagues show that administration of Milk thistle extract "
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    • "improved metabolic parameters (Federico et al., 2008; Federico et al., 2006; Loguercio et al., 2007) and prevents mitochondrial dysfunction in the rodent model of non-alcoholic steatohepatitis (Serviddio et al., 2010). It has shown to ameliorate hepatic pathology in the patients of non-alcoholic fatty liver disease (NAFLD) (Loguercio et al., 2007). In addition, SYM significantly reduces platelet adhesion and aggregation in the rat (Rui, 1991). "
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    • "Silibinin (milk thistle), a free radical scavenger with antifibrotic properties, alleviated steatohepatitis and NASH-induced lipid peroxidation when given over 12 weeks in a rat model of NASH [74]. A pilot study in patients with NAFLD found improvement in liver enzymes and insulin resistance, when silibinin was given with vitamin E and phospholipids [75]. "
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