Mammographic Pattern Analysis: An Emerging Risk Assessment Tool

Academic Radiology (Impact Factor: 1.75). 06/2007; 14(5):511-2. DOI: 10.1016/j.acra.2007.03.003
Source: PubMed
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    • "Substantial advances have been made with computer aided mammography in breast cancer research and treatment . Mammographic risk can be assessed in a clinical environment based on subjective appraisal of mammograms using protocols such as BI-RADS (American College of Radiology's Breast Imaging Reporting and Data System) [5], which can lead to inter-and intraobserver variability [6]. Within computer aided mammography, the idea of developing a fully automatic and repeatable breast tissue segmentation using computer vision and machine learning techniques is to facilitate cancer risk classification. "
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    ABSTRACT: Breast cancer is the most frequently diagnosed cancer in women. However, the exact cause(s) of breast cancer still remains unknown. Early detection, precise identification of women at risk, and application of appropriate disease prevention measures are by far the most effective way to tackle breast cancer. There are more than 70 common genetic susceptibility factors included in the current non-image-based risk prediction models (e.g., the Gail and the Tyrer-Cuzick models). Image-based risk factors, such as mammographic densities and parenchymal patterns, have been established as biomarkers but have not been fully incorporated in the risk prediction models used for risk stratification in screening and/or measuring responsiveness to preventive approaches. Within computer aided mammography, automatic mammographic tissue segmentation methods have been developed for estimation of breast tissue composition to facilitate mammographic risk assessment. This paper presents a comprehensive review of automatic mammographic tissue segmentation methodologies developed over the past two decades and the evidence for risk assessment/density classification using segmentation. The aim of this review is to analyse how engineering advances have progressed and the impact automatic mammographic tissue segmentation has in a clinical environment, as well as to understand the current research gaps with respect to the incorporation of image-based risk factors in non-image-based risk prediction models.
    07/2015; 2015:1-31. DOI:10.1155/2015/276217
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    Academic Radiology 08/2008; 15(7):813-6. DOI:10.1016/j.acra.2008.05.010 · 1.75 Impact Factor
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    ABSTRACT: Studies have demonstrated a relationship between mammographic parenchymal texture and breast cancer risk. Although promising, texture analysis in mammograms is limited by tissue superposition. Digital breast tomosynthesis (DBT) is a novel tomographic x-ray breast imaging modality that alleviates the effect of tissue superposition, offering superior parenchymal texture visualization compared to mammography. The aim of this study was to investigate the potential advantages of DBT parenchymal texture analysis for breast cancer risk estimation. DBT and digital mammographic (DM) images of 39 women were analyzed. Texture features, shown in previous studies with mammograms to correlate with cancer risk, were computed from the retroareolar breast region. The relative performances of the DBT and DM texture features were compared in correlating with two measures of breast cancer risk: (1) the Gail and Claus risk estimates and (2) mammographic breast density. Linear regression was performed to model the association between texture features and increasing levels of risk. No significant correlation was detected between parenchymal texture and the Gail and Claus risk estimates. Significant correlations were observed between texture features and breast density. Overall, the DBT texture features demonstrated stronger correlations with breast percent density than DM features (P < or = .05). When dividing the study population into groups of increasing breast percent density, the DBT texture features appeared to be more discriminative, having regression lines with overall lower P values, steeper slopes, and higher R(2) estimates. Although preliminary, the results of this study suggest that DBT parenchymal texture analysis could provide more accurate characterization of breast density patterns, which could ultimately improve breast cancer risk estimation.
    Academic radiology 03/2009; 16(3):283-98. DOI:10.1016/j.acra.2008.08.014 · 1.75 Impact Factor
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