Monophasic epithelial synovial sarcoma arising in the temporomandibular joint
Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, 1-8-1 Inohana, Chiba 260-8677, Japan.International Journal of Oral and Maxillofacial Surgery (Impact Factor: 1.57). 09/2007; 36(8):762-5. DOI: 10.1016/j.ijom.2007.02.014
Synovial sarcoma is a mesenchymal spindle-cell tumour that occurs infrequently in the head and neck. It originates from unknown stem cells differentiating into mesenchymal and/or epithelial structures. Most synovial sarcomas are biphasic in character, consisting of epithelial and spindle-cell elements. Here is reported a case of monophasic epithelial synovial sarcoma arising in the temporomandibular joint. The tumour was of a predominantly epithelial pattern, although a minute area of sarcomatous cells was found. The primary mode of treatment was wide en-bloc excision. Two years after surgery, the patient died of hepatocellular carcinoma, but there was no evidence of synovial sarcoma recurrence.
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- "It is the fourth most common type of sarcoma following malignant fibrous histiocytoma, liposarcoma and rhabdomyosarcoma. It was first documented by Simon in 1865. The term synovioma was coined by Smith in 1927 but Knox in 1936 defined it histologically. "
ABSTRACT: Synovial sarcoma is a mesenchymal spindle cell tumor with variable epithelial differentiation. It is unrelated to the synovium as the name might suggest but arises in the soft tissues of the extremities around the knee joints and tendon sheaths. The tumor cells are thought to resemble normal synovial tissue histopathologically, hence named "synovial sarcoma" (SS). Head and neck lesions are less common and oral cavity involvement is extremely rare. Few cases in tongue, soft palate, mandible, buccal mucosa and floor of mouth have been described in the literature. Here, we probably report the first case of primary biphasic SS (BSS) involving gingiva in the retromolar area of the mandible in a 21-year-old male patient.Journal of Oral and Maxillofacial Pathology 04/2014; 18(1):77-80. DOI:10.4103/0973-029X.131916
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- "Sarcomas are malignant soft tissue tumours representing only 1% of all malignant tumours and 1% of all head and neck malignancies 1. Synovial cell sarcoma (SS) is a high grade histological variety of sarcoma and it is the fourth most common entity after malignant fibrous histiocytomas, liposarcomas and rhabdomyosarcomas. It typically occurs in young adults with a male/female ratio of 2:1 2 3. It is located predominantly near large joints and bursae of the lower extremities such as knee, tendon sheaths and bursal structures, but is rarely found in the head and neck (representing only 3% to 10% of synovial cell sarcomas and quite often the correlation with synovial structures remains unclear), because this region is poor in synovioblastic tissue 4. However, the most common sites of localization, in the head and neck region, are hypopharynx and parapharyngeal spaces. "
ABSTRACT: Parotid gland tumours are very heterogeneous, being benign in 80% of cases, and generally arising from epithelial cells. Nevertheless, a small group of non-epithelial tumours representing just 5% of all salivary gland neoplasms has also been reported, the most common of these being haemangioma, especially in children. However, lymphomas, neuromas, neurofibromas, lipomas and sarcomas can also be found. Synovial cell sarcoma is a high grade histological variety of sarcoma and is generally located near large joints and bursae of the lower extremities, such as knee, tendon sheaths and bursal structures. It is rarely found in the head and neck region due to its lack of synovioblastic tissue. Herewith, the case of a young female, affected by a synovial sarcoma of the left parotid gland, is presented and a review is made of the literature on this rare specific localization focusing on management and outcome.Acta otorhinolaryngologica Italica: organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale 02/2011; 31(1):43-6. · 1.64 Impact Factor
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ABSTRACT: Synovial sarcoma is a distinctive soft tissue neoplasm with monophasic and biphasic forms. It is typically a deep-seated soft tissue tumour of the extremities of young adults and occasional cases have been described in large peripheral nerves. A rare example has a predominance of the glandular component and may mimic metastatic carcinoma. Here, a unique synovial sarcoma with <1% spindle cell component involving the posterior tibial nerve is decribed. In addition to having only small bands or islands of stroma, there was also mucin dissection of the surrounding soft tissue. Isolated glands were seen "floating" in pools of mucin. There was abundant intracellular mucin present as well. These latter two findings have not been described in synovial sarcoma thus far, to our knowledge. The diagnosis was confirmed by molecular detection of the t(X;18) by reverse transcription-PCR and confirmed by dual colour break apart fluorescence in situ hybridisation, in a second laboratory. Mucinous, gland predominant synovial sarcoma must be recognised to avoid misdiagnosis of metastatic carcinoma or a glandular malignant peripheral nerve sheath tumour when occurring in a peripheral nerve.Journal of clinical pathology 06/2008; 61(5):672-6. DOI:10.1136/jcp.2007.053124 · 2.92 Impact Factor
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