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# A biocompatibility study of a reinforced acrylic based hybrid denture composite resin with polyhedraligosilsesquioxane

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Department of Prosthodontics and Dental Research Institute, College of Dentistry, Seoul National University, Seoul, Korea.
(Impact Factor: 1.93). 06/2007; 34(5):389-95. DOI: 10.1111/j.1365-2842.2006.01671.x
Source: PubMed

ABSTRACT Acrylic-based denture materials have several common weak points, such as shrinkage after curing, lack of strength and toxicity. In order to solve these problems, we adapted a hybrid system using acrylic polymer and polyhedraloligosilsesquioxane (POSS). The aim of the study was to investigate the biocompatibility of a reinforced acrylic-based hybrid denture composite resin with POSS. Specimens of a novel polymeric denture base resin, in which POSS was used to partially replace the commonly used base monomer, were fabricated. In order to examine changes in biocompatibility with time, fresh specimens, along with specimens soaked in distilled water for 24 and 72 h were fabricated. Three other types of acrylic denture base resins were used to prepare the resin specimens. Biocompatibility (as measured by a metabolic assay, an agar overlay test, and a mutagenesis assay) of the composites was tested. The metabolic and mutagenesis assays were conducted with pure culture medium as a control. In this study, the reinforced acrylic-based hybrid denture composite resin with POSS showed improved biocompatibility and lower mutagenicity than the control. Statistical examinations showed the cell metabolic activity of the novel polymeric denture base resin in the 72-h immersion case as having almost the same inclination as the control. We hope that these results might aid in the development of a reinforced acrylic-based denture resin.

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• "Microbial adhesion has also been a limiting factor for other PMMA biomedical applications, such as ophthalmic prostheses, contact lenses and bone repair [6] [7]. Other weak points of PMMA materials include lack of strength and toxicity [8]. Therefore, the search for innovative solutions addressing these problems is of special interest in the development of acrylic materials-based implants. "
##### Article: Biocompatible Metal-Oxide Nanoparticles: Nanotechnology Improvement of Conventional Prosthetic Acrylic Resins
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ABSTRACT: Nowadays, most products for dental restoration are produced from acrylic resins based on heat-cured Poly(Methyl MethAcrylate) (PMMA). The addition of metal nanoparticles to organic materials is known to increase the surface hydrophobicity and to reduce adherence to biomolecules. This paper describes the use of nanostructured materials, TiO2 and Fe2O3, for simultaneously coloring and/or improving the antimicrobial properties of PMMA resins. Nanoparticles of metal oxides were included during suspension polymerization to produce hybrid metal oxides-alginate-containing PMMA. Metal oxide nanoparticles were characterized by dynamic light scattering, and X-ray diffraction. Physicochemical characterization of synthesized resins was assessed by a combination of spectroscopy, scanning electron microscopy, viscometry, porosity, and mechanical tests. Adherence of Candida albicans cells and cellular compatibility assays were performed to explore biocompatibility and microbial adhesion of standard and novel materials. Our results show that introduction of biocompatible metal nanoparticles is a suitable means for the improvement of conventional acrylic dental resins.
Journal of Nanomaterials 01/2011; DOI:10.1155/2011/941561 · 1.64 Impact Factor
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• "On the other hand, Pan et al. (2006) have summarized the recent progress in hybrid electroluminescent materials and hybrid liquid crystals based on POSS as well as the self-assembly behavior of POSS derivatives. Polymeric POSS have also shown significant promise for use in biomedical applications, such as tissue implants (Kannan et al. 2007), dental materials (Kim et al. 2007; Siang Soh et al. 2006), and drug delivery materials (McCusker et al. 2005). "
##### Article: Viscoelastic properties of POSS–styrene nanocomposite blended with polystyrene
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ABSTRACT: Polyhedral oligomeric silsesquioxane (POSS) are hybrid nanostructures of about 1.5nm in size. These silicon (Si)-based polyhedral nanostructures are attached to a polystyrene (PS) backbone to produce a polymer nanocomposite (POSS–styrene). We have solution blended POSS–styrene of [(M)]w = 14.5103g/mol\overline{M}_w =14.5\times 10^3\;\rm{g/mol} with commercial polystyrene (PS), [(M)]w = 2.8105g/mol\overline{M}_w =2.8\times 10^5\;\rm{g/mol}, and studied the rheological behavior and thermal properties of the neat polymeric components and their blends. The concentration of POSS–styrene was varied from 3 up to 20wt.%. Thermal analysis studies suggest phase miscibility between POSS–styrene and the PS matrix. The blends displayed linear viscoelastic regime and the time–temperature superposition principle applied to all blends. The flow activation energy of the blends decreased gradually with respect to the matrix as the POSS–styrene concentration increased. Strikingly, it was found that POSS–styrene promoted a monotonic decrease of zero-shear rate viscosity, η 0, as the concentration increased. Rheological data analyses showed that the POSS–styrene increased the fractional free volume and decreased the entanglement molecular weight in the blends. In contrast, blending the commercial PS with a PS of [`(M)]w = 5103g/mol\overline{M}_w =5\times 10^3\;\rm{g/mol} did not show the same lubrication effect as POSS–styrene. Therefore, it is suggested that POSS particles are responsible for the monotonic reduction of zero-shear rate viscosity in the blends.
Rheologica Acta 07/2009; 48(6):641-652. DOI:10.1007/s00397-009-0358-8 · 1.78 Impact Factor
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##### Article: Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles
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ABSTRACT: The antimicrobial effect and biocompatibility of insoluble cross-linked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1 or 2%w/w in a resin composite were assayed. The antimicrobial effect against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli was tested using the direct contact test (DCT), agar diffusion test (ADT) and scanning electron microscopy (SEM). Biocompatibility was tested by assessing macrophage viability, and TNFalpha secretion. Samples incorporating 2%w/w nanoparticles inhibited the growth of all bacterial strains tested. Reducing the amount of the added nanoparticles to 1%w/w resulted in complete inhibition of S. aureus and E. faecalis, and decreased growth of S. epidermidis, P. aeruginosa and E. coli (p<0.0001). The DCT results were confirmed by SEM. However, ADT showed no inhibition halo in all test bacteria, indicating the antimicrobial nanoparticles are not diffusing into the agar milieu. Biocompatibility tests revealed macrophage viability, and TNFalpha secretion was not altered by the presence of the nanoparticles in the resin. Incorporation of PEI nanoparticles in a resin composite had a long lasing antimicrobial effect against a wide range of bacteria with no measured effect on biocompatibility.
Biomaterials 11/2008; 29(31):4157-63. DOI:10.1016/j.biomaterials.2008.07.003 · 8.31 Impact Factor