A biocompatibility study of a reinforced acrylic based hybrid denture composite resin with polyhedraligosilsesquioxane

Department of Prosthodontics and Dental Research Institute, College of Dentistry, Seoul National University, Seoul, Korea.
Journal of Oral Rehabilitation (Impact Factor: 1.68). 06/2007; 34(5):389-95. DOI: 10.1111/j.1365-2842.2006.01671.x
Source: PubMed


Acrylic-based denture materials have several common weak points, such as shrinkage after curing, lack of strength and toxicity. In order to solve these problems, we adapted a hybrid system using acrylic polymer and polyhedraloligosilsesquioxane (POSS). The aim of the study was to investigate the biocompatibility of a reinforced acrylic-based hybrid denture composite resin with POSS. Specimens of a novel polymeric denture base resin, in which POSS was used to partially replace the commonly used base monomer, were fabricated. In order to examine changes in biocompatibility with time, fresh specimens, along with specimens soaked in distilled water for 24 and 72 h were fabricated. Three other types of acrylic denture base resins were used to prepare the resin specimens. Biocompatibility (as measured by a metabolic assay, an agar overlay test, and a mutagenesis assay) of the composites was tested. The metabolic and mutagenesis assays were conducted with pure culture medium as a control. In this study, the reinforced acrylic-based hybrid denture composite resin with POSS showed improved biocompatibility and lower mutagenicity than the control. Statistical examinations showed the cell metabolic activity of the novel polymeric denture base resin in the 72-h immersion case as having almost the same inclination as the control. We hope that these results might aid in the development of a reinforced acrylic-based denture resin.

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    • "Microbial adhesion has also been a limiting factor for other PMMA biomedical applications, such as ophthalmic prostheses, contact lenses and bone repair [6] [7]. Other weak points of PMMA materials include lack of strength and toxicity [8]. Therefore, the search for innovative solutions addressing these problems is of special interest in the development of acrylic materials-based implants. "
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    Journal of Nanomaterials 01/2011; 2011(1). DOI:10.1155/2011/941561 · 1.64 Impact Factor
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    • "On the other hand, Pan et al. (2006) have summarized the recent progress in hybrid electroluminescent materials and hybrid liquid crystals based on POSS as well as the self-assembly behavior of POSS derivatives. Polymeric POSS have also shown significant promise for use in biomedical applications, such as tissue implants (Kannan et al. 2007), dental materials (Kim et al. 2007; Siang Soh et al. 2006), and drug delivery materials (McCusker et al. 2005). "
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