Article

The metabolic consequences of sleep deprivation

Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 1027, Chicago, IL 60637, USA.
Sleep Medicine Reviews (Impact Factor: 9.14). 07/2007; 11(3):163-78. DOI: 10.1016/j.smrv.2007.01.002
Source: PubMed

ABSTRACT The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2-3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: (1) alterations in glucose metabolism; (2) upregulation of appetite; and (3) decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.

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Available from: Kristen L Knutson, Aug 23, 2015
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    • "Together with evidence that many people are permanently sleep deprived (Valdez et al. 1996; Duffy et al. 2001, Duffy and De Gennaro, 2001; Moore et. al., 2002; Roenneberg et al., 2007; Knutson et al., 2007) and the link between sleep deprivation and bad health (Pilcher and Huffcutt, 1996; Pilcher et al., 1997; Pilcher and Ott, 1998; Ferrara and De Gennaro, 2001; Ayas et al., 2003; Taheri et al., 2004; Mullington, et al., 2009), this finding is one of the first quasi-experimental studies showing that sleep may lead to significant, immediate, health improvements for people on the margin to getting hospitalized. "
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