The metabolic consequences of sleep deprivation

Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 1027, Chicago, IL 60637, USA.
Sleep Medicine Reviews (Impact Factor: 8.51). 07/2007; 11(3):163-78. DOI: 10.1016/j.smrv.2007.01.002
Source: PubMed


The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2-3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: (1) alterations in glucose metabolism; (2) upregulation of appetite; and (3) decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.

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Available from: Kristen L Knutson,
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    • "Sleep is a complex and critical biological process that is impacted by both genetic and non-genetic factors in humans. Inadequate sleep can lead to several health issues such as impaired immune function [Aldabal and Bahammam, 2011], increased risk for type II diabetes and obesity [Knutson et al., 2007], and cognitive impairment [Van Dongen et al., 2003; Durmer and Dinges, 2005]. Furthermore, sleep deprivation is associated with common psychiatric conditions such as anxiety and depression [van Mill et al., 2010]. "
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    • "These findings have been consistently supported in the research, such as in a large (N = 3,427) study of Australian children, which found a bidirectional relationship between sleep duration and children's media use (Magee et al., 2014). Sleep deprivation is a health issue as it is associated with increased risk of obesity and diabetes (Knutson et al., 2007), as well as by guest on August 24, 2015 Downloaded from negative cognitive issues including tiredness, difficulty concentrating and irritability, which can 'mimic attention deficiency hyperactivity disorder' (Dahl, 1996: 44). "
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    • "Together with evidence that many people are permanently sleep deprived (Valdez et al. 1996; Duffy et al. 2001, Duffy and De Gennaro, 2001; Moore et. al., 2002; Roenneberg et al., 2007; Knutson et al., 2007) and the link between sleep deprivation and bad health (Pilcher and Huffcutt, 1996; Pilcher et al., 1997; Pilcher and Ott, 1998; Ferrara and De Gennaro, 2001; Ayas et al., 2003; Taheri et al., 2004; Mullington, et al., 2009), this finding is one of the first quasi-experimental studies showing that sleep may lead to significant, immediate, health improvements for people on the margin to getting hospitalized. "
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    Report number: IZA Discussion Paper 9088
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