The metabolic consequences of sleep deprivation

Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 1027, Chicago, IL 60637, USA.
Sleep Medicine Reviews (Impact Factor: 9.14). 07/2007; 11(3):163-78. DOI: 10.1016/j.smrv.2007.01.002
Source: PubMed

ABSTRACT The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2-3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: (1) alterations in glucose metabolism; (2) upregulation of appetite; and (3) decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.

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Available from: Kristen L Knutson, Aug 23, 2015
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    • "Together with evidence that many people are permanently sleep deprived (Valdez et al. 1996; Duffy et al. 2001, Duffy and De Gennaro, 2001; Moore et. al., 2002; Roenneberg et al., 2007; Knutson et al., 2007) and the link between sleep deprivation and bad health (Pilcher and Huffcutt, 1996; Pilcher et al., 1997; Pilcher and Ott, 1998; Ferrara and De Gennaro, 2001; Ayas et al., 2003; Taheri et al., 2004; Mullington, et al., 2009), this finding is one of the first quasi-experimental studies showing that sleep may lead to significant, immediate, health improvements for people on the margin to getting hospitalized. "
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    • "an individual ' s sleep - wake cycle can be impacted because many jobs require specific time commitments ( Roenneberg et al . , 2007 ) . When this cycle is disrupted , which has been shown to be common for individuals with an evening preference ( Kanerva et al . , 2012 ) , it can negatively influence an individual ' s circadian rhythm and health ( Knutson et al . , 2007 ) . Based on the results of the current study , we further posit that this underlying biological mechanism , in part , drives the relationship between the personality factors and eating behavior . That is , circadian rhythm disruptions , commonly seen in individuals with an evening preference , might be the force causing time - of - day"
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    • "Due to the complexity of the analytic model and our limited sample size, we first investigated a model with no covariates except for baseline ghrelin or hunger levels. For the primary analysis, we added potential confounds that were selected based on their theoretical and empirical relationships to loneliness, ghrelin, and hunger (Di Francesco et al., 2006; Knutson et al., 2007; Koliaki et al., 2010; Taheri et al., 2004). The adjusted models included age, syndromal depression, meal type, and sleep duration; we also added cancer status as a covariate due to the design of the parent study. "
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