Primary malignant fibrous histiocytoma of the heart
Division of Cardiovascular Surgery, Nagasaki Kouseikai Hospital, 1-3-12 Hayama, Nagasaki 852-8053, Japan.General Thoracic and Cardiovascular Surgery 02/2007; 55(1):29-31. DOI: 10.1007/s11748-006-0060-z
We describe a case of a primary cardiac malignant fibrous histiocytoma in the left atrium of a 72-year-old man. Local recurrences appeared twice, at 2 and 14 months after initial tumor resection, and were managed surgically. The patient died of pancreatic metastasis 22 months after the initial diagnosis. The prognosis for MFH of the heart is poor despite aggressive surgical treatment.
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ABSTRACT: We reported three cases of polypoid tumor of the esophagus, among them one case of sarcomatous tumor partly covered with superficial squamous cell carcinoma. The sarcoma was consisted of anaplastic spindle and pleomorphic tumor cells, which was similar to malignant fibrous histiocytoma (MFH) of the soft tissue. Diagnosis of the surgery resected specimen was confirmed by histological, immunohistochemical and electron microscopic methods. Both diagnostic and differential diagnostic problems of primary MFH of the esophagus and world medical literatures were discussed.The Chinese-German Journal of Clinical Oncology 10/2007; 6(5):503-506. DOI:10.1007/s10330-007-0083-7
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ABSTRACT: Diagnosis of malignant fibrous histiocytoma in ileal and atrial locations is uncommon and diagnosis of synchronous lesions in both locations is exceptional. We present the case of a 60-year-old woman with a malignant fibrous histiocytoma in both locations. Malignant fibrous histiocytoma is an aggressive neoplasm. Definitive diagnosis is histological. Immunochemistry helps to establish the differential diagnosis with other entities.Gastroenterología y Hepatología 01/2008; 31(1). DOI:10.1157/13114579 · 0.84 Impact Factor
Article: Primary Malignant Cardiac Tumors[Show abstract] [Hide abstract]
ABSTRACT: Objectives: Primary malignant cardiac tumors are rare but aggressive. The malignant tumors mainly consist of various sarcomas which account for 90-95% of primary malignancies of the heart. Pathology and immunohistochemistry of the cardiac malignancies have not been sufficiently described. Methods: The pathology, in particular the immunohistochemistry, of the primary malignant cardiac tumors were collected from the literature and analyzed. Results: Cardiac sarcomas were usually positive to intermediate filament proteins (desmin, vimentin and keratin), myogenic markers (actins, caldesmon and myogenin) and endothelial markers (CD34, CD31, factor VIII-related proteins and FLI1), whereas rhabdomyosarcoma and synovial sarcoma could be positive to Schwannian and/or epithelial-related markers. Conclusions: Positive reactions to the endothelial markers can be helpful in distinguishing the reactive mesothelial from malignant cells. The evidence for the definite diagnosis of the cardiac malignancies may lead to a prompt treatment either by surgery and/or chemotherapy even though the patients often have poor survival.Acta Medica Mediterranea 01/2013; 29(2):219-225. · 0.11 Impact Factor
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