Particle size of LDL is affected by the National Cholesterol Education Program (NCEP) step II diet in dyslipidaemic adolescents

Shahid Beheshti University of Medical Sciences, Teheran, Tehrān, Iran
British Journal Of Nutrition (Impact Factor: 3.34). 07/2007; 98(1):134-9. DOI: 10.1017/S0007114507657857
Source: PubMed

ABSTRACT The objective was to determine the effects of the National Cholesterol Education Program (NCEP) step II diet on LDL and HDL particle size in dyslipidaemic adolescents. Forty-four dyslipidaemic adolescents, aged 10-18 years, participated in this case-control study. The control diet was a diet similar to what most Tehranian adolescents eat. NCEP step II diet was a diet with 30 % of energy as total fat, less than 7 % saturated fat, less than 200 mg cholesterol/d, less than 15 % of energy as MUFA and less than 10 % as PUFA. Lipoprotein particle size was the major outcome variable, which was measured after 3 months of intervention. Comparison was made by the repeated measurement ANOVA. The mean BMI was 26.3 (sd 4.2) kg/m2. There were no significant changes in weight or physical activity in the two groups during the study. The NCEP diet resulted in higher reduction in total cholesterol ( - 13 (sd 4) v. - 2 (sd 0.3) mg/dl, P < 0.001) and LDL ( - 9 (sd 2) v. 3 (sd 0.6) mg/dl, P < 0.01), and higher increase in size of the LDL (1.7 (sd 0.4) v. 0.1 (sd 0.4) nanometer, P < 0.001). HDL particle size did not change significantly. NCEP step II diet had a favourable effect on the LDL particle size. The related mechanism needs to be studied in future experimental designs.


Available from: Parvin Mirmiran, May 29, 2015
  • [Show abstract] [Hide abstract]
    ABSTRACT: A high serum cholesterol is a well-established major risk factor for coronary heart disease (CHD). Evidence that supports the lipid hypothesis includes research in animal models, epidemiological studies, studies of genetic forms of hyperlipidemia, and laboratory and clinical trials of cholesterol-lowering therapy. Low-density lipoprotein cholesterol (LDL-C) is the major atherogenic lipoprotein and has been designated the primary target of therapy by the National Cholesterol Education Program (NCEP) [1]. KeywordsDirect LDL-LDL phenotyping-Apolipoprotein B-Lipoprotein(a)-High-sensitivity C-reactive protein-Lp-PLA2
    04/2011: pages 77-103;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Atherosclerosis represents a disease that begins in childhood, and alterations in lipid concentration play a fundamental role in the development of this condition. Children and adolescents with high cholesterol levels are more likely than their peers in the general population to present with dyslipidemia in adulthood. Precocious identification of dyslipidemias associated with premature cardiovascular disease is crucial during childhood to delay or prevent the atherosclerotic process. The National Cholesterol Education Program has established guidelines for the diagnosis and treatment of dyslipidemia during pediatric age. It has been suggested that a heart-healthy diet should begin at 2 years of age, and no adverse effects on psychological aspects, growth, pubertal development and nutritional status in children and adolescents limiting total and saturated fat intake have been demonstrated. Pharmacotherapy should be considered in children aged 10 years or older when low-density lipoprotein cholesterol concentrations remain very high despite dietary therapy, especially when multiple risk factors are present. The lipid-lowering drugs recommended for childhood and adolescence are resins and statins. The increasing use of statins is dependent on their effectiveness and safety. Ezetimibe, a selective cholesterol absorption inhibitor, may provide a similar cholesterol-lowering effect as that reached with statin treatment. This review provides an update on recent advances in the therapy of dyslipidemia, especially hypercholesterolemia, during pediatric age and adolescence.
    Expert Review of Endocrinology &amp Metabolism 08/2008; 3(5):615-633. DOI:10.1586/17446651.3.5.615
  • [Show abstract] [Hide abstract]
    ABSTRACT: Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease (CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolescents (15.0 ± 1.0 years) completed a 12-week nutrition education and exercise intervention. Low-density lipoprotein (LDL) particle size and distribution of cholesterol in lipoprotein subclasses were determined via polyacrylamide gel electrophoresis. The intervention resulted in increases in mean LDL particle size (269.3 ± 3.4 to 271.6 ± 2.9 Å, P = 0.0003) and cholesterol in large high-density lipoprotein (HDL) subfractions (22.4 ± 11.2 to 26.8 ± 10.6% area, P = 0.007) along with decreases of cholesterol in small LDL (1.6 ± 2.0 to 0.6 ± 1.2% area, P < 0.01) and HDL subfractions (23.2 ± 9.4 to 19.0 ± 6.7% area, P = 0.05). These improvements were observed independent of changes in weight (90.7 ± 26.2 to 89.9 ± 27.8 kg, P > 0.05) and suggest that lifestyle modification in obese youth may reduce cardiovascular risk by shifting lipoprotein particle size and cholesterol distribution to a less atherogenic phenotype.
    Pediatric Obesity 04/2013; 8(5). DOI:10.1111/j.2047-6310.2013.00162.x · 2.42 Impact Factor