Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens"

Harvard University, Cambridge, Massachusetts, United States
Science (Impact Factor: 31.48). 05/2007; 316(5823):370. DOI: 10.1126/science.1137568
Source: PubMed

ABSTRACT Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1720) suggested that ASPM, a gene associated with microcephaly, underwent natural selection within the last 500 to 14,100 years. Their analyses based on comparison with computer simulations indicated that ASPM had an unusual pattern of variation. However, when we compare ASPM empirically to a large number of other loci, its variation is not unusual and does not support selection.


Available from: Eric Wang, Mar 03, 2014
1 Follower
  • [Show abstract] [Hide abstract]
    ABSTRACT: The lack of association of the abnormal spindle-like microcephaly associated (ASPM) and Microcephalin (MCPH1) genes with brain size or intelligence described by Timpson et al. has been reported previously, including by our own group. Moreover, as in most studies of selection, our analyses were entirely independent of phenotypic association. We also respond to the previously published comment by Yu et al., which argued that ASPM has not undergone positive selection.
    Science 08/2007; 317(5841):1036-1036. DOI:10.1126/science.1143658 · 31.48 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Recently Song et al. Phys. Rev. A 80 012331 (2009) discovered that certain two-qutrit entangled states interacting with multilocal dephasing undergo distillability sudden death (DSD). We generalized their studies for quantum states under global, collective, and multilocal dephasing. We found that for a specific family of quantum states DSD and entanglement sudden death may happen under global dephasing as well as under multilocal dephasing. Moreover, for these states simple local unitary transformations may not avoid DSD under the current dynamics. As there is no definitive criterion for separability or entanglement of density matrices with dimensions greater than six, therefore we believe that the results obtained in this article are restricted to the specific family of states considered here.
    Physical Review A 04/2010; 81(4). DOI:10.1103/PhysRevA.81.042303 · 2.99 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Based on the exactly analytic solution obtained of the intensity-dependent Jaynes-Cummings model for a certain class of initial entangled mixed states, we explore the time evolution of the entanglement between two atoms, initially non-locally correlated and separately interacting with two distinct cavities. The results show that entanglement sudden death is dependent on the different initial states of atoms, and the length of the time interval for the zero entanglement is invariant for a certain class of initial mixed states.
    Modern Physics Letters B 10/2008; 22(25):2503-2508. DOI:10.1142/S021798490801687X · 0.69 Impact Factor