Article

2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols.

Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
Bioorganic & Medicinal Chemistry (impact factor: 2.92). 07/2007; 15(12):3990-6. DOI:10.1016/j.bmc.2007.04.004 pp.3990-6
Source: PubMed

ABSTRACT The allylation of appropriate benzoin in presence of indium metal followed by m-CPBA mediated cyclization gave 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols. Investigations on 59 human tumor cell lines of these compounds identify four compounds exhibiting significant growth inhibition of tumor cells at particular cell lines. Compound 12 is very specific toward CCRF-CEM and SR cell lines of leukemia.

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Keywords

59 human tumor cell lines
 
appropriate benzoin
 
CCRF-CEM
 
compounds
 
indium metal
 
Investigations
 
particular cell lines
 
significant growth inhibition
 
SR cell lines
 
tumor cells
 

Palwinder Singh