Article

Innate immunity of the newborn: Basic mechanisms and clinical correlates

Department of Medicine, Division of Infectious Diseases, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
Nature reviews. Immunology (Impact Factor: 33.84). 06/2007; 7(5):379-90. DOI: 10.1038/nri2075
Source: PubMed

ABSTRACT The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses that can lead to pre-term delivery, and balancing the transition from a sterile intra-uterine environment to a world that is rich in foreign antigens. These demands shape a distinct neonatal innate immune system that is biased against the production of pro-inflammatory cytokines. This bias renders newborns at risk of infection and impairs responses to many vaccines. This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population.

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Available from: Ofer Levy, Jul 25, 2015
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    • "Il est largement e ´tabli que tous ces mécanismes cellulaires, aptes a ` assurer cette réponse immunitaire du chorion sousmuqueux intestinal, ne sont pas absents chez le jeune nourrisson mais qu'ils sont encore immatures [9] [26] [33]. Les récepteurs dendritiques CD103 + , plus aptes a ` favoriser la réponse de tolérance de la CD, et donc a ` orienter le lymphocyte CD4 + naı¨f dans sa transformation en cellule iTreg, sont encore immatures [26]. "
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