Vanadium (V) is a transition metal emitted to the atmosphere during the combustion of fossil fuels. Its current status as an atmospheric pollutant increases the need for information about the effects that this element might have on the reproductive health of exposed populations. The present study investigated changes in testicular ultrastructure following inhalation exposure of male mice to V (as vanadium pentoxide). Tissue V level was constant during the 12-week time period. We observed necrosis of spermatogonium, spermatocytes and Sertoli cells, as well as pseudo-nuclear inclusion and disruption of cellular junctions. Our findings stressed the importance of the hemato-testicular barrier in supporting the function of Sertoli cells and suggest as a possible target of V, tight junction proteins. Further analysis is needed in order to identify the role that reactive oxidative species (ROS) might have on these cellular junctions, and if a specific protein is the target of its toxic effects. The relevance of this report concerns the impact that metal air pollution could have on male fertility in dense cities with vehicular traffic problems.
"Vanadyum: Cam, seramik ve kimya endüstrisi ile kaynakçılık atıkları başlıca kirlenme nedenidir (Dökmeci 2001). Fosil yakıtlarının yanması sonucu atmosfere salınan vanadyuma inhalasyon yoluyla maruz bırakılan farelerde, yapılan spermatogonyum, spermatositler ve Sertoli hücrelerinde nekroz belirlenmiştir (Fortoul ve ark. 2007). Oral yolla 60 gün boyunca 9.4 ppm vanadyum tetraoksit verilen farelerde seminifer tubullerde dejeneratif değişiklikler ortaya çıkmış ve testosteron seviyeleri düşmüştür (Mathur ve ark. 2010). Ağır metallerin invitro reprodüktif toksisitesini belirlemek için yapılan çalışmada (Castellini ve ark. 2009) vanadyum, krom ve cıvadan sonra sp"
[Show abstract][Hide abstract] ABSTRACT: ZET Üreme sistemi, çevreye yayılan kimyasal kirleticiler karşı duyarlıdır. Endüstrileşme, son kırk yılda çevre kirliliğinin artmasından sorumlu önemli bir etkendir. Bazı ağır metallere maruz kalma, infertilite de dahil çok farklı istenmeyen etkilere yol açar. Ağır metallerin üreme sistemi üzerine olan etkileri büyük sağlık sorunu haline gelmiştir. Bu nedenle bu derlemenin amacı, üreme sistemi üzerine bazı metallerin etkilerine dikkat çekmektir. SUMMARY The reproductive system is sensitive to chemical pollutants that are widely distributed in the environment. Industrialization is an important factor responsible for boom in the environmental pollution in last four decades. Exposure to some heavy metals has been associated to a huge variety of adverse effects including infertility. The effects of heavy metals on reproductive system have become great health problem. Hence, the aim of this review is to highlight the effects of some metals on reproductive system.
Veteriner Fakültesi dergisi 01/2013; · 0.22 Impact Factor
"Workers occupationally exposed to vanadium are at risk of developing respiratory diseases (IARC, 2006) and increased heart rates (Magari et al., 2002), because respirable particulates may penetrate deep into the pulmonary tract. Experimental studies in rodents have shown that chronic inhalation of vanadium(V) pentoxide causes bronchiole-alveolar neoplasms (NTP, 2002), histological changes and functional damage to the spleen, neuronal damage and ultrastructural alterations in the seminiferous tubules (Ávila-Costa et al., 2006; Fortoul et al., 2007; Piñón-Zárate et al., 2008). In human-cultured lung fibroblasts, vanadium exposure induces the expression of genes that mediate inflammation and immune responses and suppresses genes involved in growth arrest. "
[Show abstract][Hide abstract] ABSTRACT: Vanadium and vanadium salts cause genotoxicity and elicit variable biological effects depending on several factors. In the present study, we analyzed and compared the DNA damage and repair processes induced by vanadium in three oxidation states. We used human blood leukocytes in vitro and in a single cell gel electrophoresis assay at two pH values. We observed that vanadium(III) trioxide and vanadium(V) pentoxide produced DNA single-strand breaks at all of the concentrations (1, 2, 4, or 8 μg/ml) and treatment times (2, 4, or 6 h) tested. Vanadium(IV) tetraoxide treatment significantly increased DNA damage at all concentrations for 4 or 6 h of treatment but not for 2 h of treatment. The DNA repair kinetics indicated that most of the cells exposed to vanadium III and V for 4 h recovered within the repair incubation time of 90 min; however, those exposed to vanadium(IV) repaired their DNA within 120 min. The data at pH 9 indicated that vanadium(IV) tetraoxide induced DNA double-strand breaks. Our results show that the genotoxic effect of vanadium can be produced by any of its three oxidation states. However, vanadium(IV) induces double-strand breaks, and it is known that these lesions are linked with forming structural chromosomal aberrations.
Toxicology in Vitro 07/2011; 25(8):1996-2002. DOI:10.1016/j.tiv.2011.07.009 · 2.90 Impact Factor
"Finally chronic ingestion of vanadium may have significant consequences for fertility by damaging spermatogenesis. Studies in mice have demonstrated that inhalation of vanadium pentoxide results in necrosis of spermatogonium, spermatocytes and Sertoli cells (Fortoul et al., 2007). Vanadium accumulates in the testes and attenuates the percentage of gammatubulin in all analyzed testicular cells, suggesting changes in the microtubules used in cell division (Mussali et al., 2005). "
[Show abstract][Hide abstract] ABSTRACT: Atmospheric pollution has been a nightmare in human technological development, which is being reflected worldwide. The worst scenarios are located in developing countries such as those located in Latin America, Asia and Africa. An interesting phenomena has been reported by Campell and Campell (2007) that they defines as "flattening of the cities" which is related with the spread of human settlements in periurban regions far from the city and health care facilities; also these settlements promote erosion, which facilitates particulate air pollution. This changes increase the need for transportation and the increase in traffic jams, as well as the accretion of atmospheric pollutants. The Vehicular Traffic Factor The health impact that inhaled particulate matter has on human health and its association with myocardial infarctions, thromboembolic diseases and other related health problems has increase. Peters et al. (2004) identified the association of traffic-related air pollution and an increase in myocardial infarction events. Some factors increased de risk such as strenuous exercise, and there were no differences if the subject was riding a bicycle, or being transported in public transportation, made no difference. The report mentioned that women and subjects over 60 years of age or older, and patients with diabetes were at higher risk for the onset of an infarction when compared with men, non diabetic or subjects younger 60 years old, after the exposure to traffic. Stress, air pollution, and noise, as well as, individual The exclusive license for this PDF is limited to personal website use only. No part of this digital document may be reproduced, stored in a retrieval system or transmitted commercially in any form or by any means. The publisher has taken reasonable care in the preparation of this digital document, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein. This digital document is sold with the clear understanding that the publisher is not engaged in rendering legal, medical or any other professional services.
Traffic Related Air Pollution and Internal Combustion Engines, 1 edited by Sergey Demidov and Jacques Bonnet, 01/2009: chapter 1: pages 1-28; Nova Publishers., ISBN: 978-1-60741-145-1
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