Article

Ultrastructural findings in murine seminiferous tubules as a consequence of subchronic vanadium pentoxide inhalation.

Cellular and Tisular Biology Department, School of Medicine, National University of Mexico, CP 04510 Mexico City, Mexico.
Reproductive Toxicology (Impact Factor: 3.14). 07/2007; 23(4):588-92. DOI: 10.1016/j.reprotox.2007.03.004
Source: PubMed

ABSTRACT Vanadium (V) is a transition metal emitted to the atmosphere during the combustion of fossil fuels. Its current status as an atmospheric pollutant increases the need for information about the effects that this element might have on the reproductive health of exposed populations. The present study investigated changes in testicular ultrastructure following inhalation exposure of male mice to V (as vanadium pentoxide). Tissue V level was constant during the 12-week time period. We observed necrosis of spermatogonium, spermatocytes and Sertoli cells, as well as pseudo-nuclear inclusion and disruption of cellular junctions. Our findings stressed the importance of the hemato-testicular barrier in supporting the function of Sertoli cells and suggest as a possible target of V, tight junction proteins. Further analysis is needed in order to identify the role that reactive oxidative species (ROS) might have on these cellular junctions, and if a specific protein is the target of its toxic effects. The relevance of this report concerns the impact that metal air pollution could have on male fertility in dense cities with vehicular traffic problems.

0 Bookmarks
 · 
76 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Exposure to electromagnetic pulses in certain doses may lead to increase in the permeability of the blood testes barrier (BTB) in mice, which in turn affects spermatogenesis, penetration and spermiation. TGF-β3 is a key molecule involved in BTB permeability via regulation of tight junction proteins, and it participates in regulating spermatogenesis, synthesis of steroids and production of the extracellular matrix in testicular tissue. Therefore, it is hypothesized that TGF-β3 plays important roles in electromagnetic pulse (EMP)-induced changes in BTB permeability. In the present study, we carried out whole-body irradiation on mice using EMP of different intensities. No obvious pathological changes or significant increase in apoptosis was detected in testicular tissues after exposure to 100 and 200 pulses of intensity 200kV/m; however, with 400 pulses we observed the degeneration and shrinkage of testicular tissues along with a significant increase in apoptotic rate. Moreover, in the 100- and 200-EMP groups, a non-significant increase in TGF-β3 mRNA and protein expression was observed, whereas in the 400-EMP group a significant increase was observed (P < 0.05). These results indicate that increase in the apoptotic rate of testicular tissues and increase in TGF-β3 expression may be one of the mechanisms for EMP-induced increase in BTB permeability in mice.
    Toxicology 05/2013; · 4.02 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Atmospheric pollution has been a nightmare in human technological development, which is being reflected worldwide. The worst scenarios are located in developing countries such as those located in Latin America, Asia and Africa. An interesting phenomena has been reported by Campell and Campell (2007) that they defines as "flattening of the cities" which is related with the spread of human settlements in periurban regions far from the city and health care facilities; also these settlements promote erosion, which facilitates particulate air pollution. This changes increase the need for transportation and the increase in traffic jams, as well as the accretion of atmospheric pollutants. The Vehicular Traffic Factor The health impact that inhaled particulate matter has on human health and its association with myocardial infarctions, thromboembolic diseases and other related health problems has increase. Peters et al. (2004) identified the association of traffic-related air pollution and an increase in myocardial infarction events. Some factors increased de risk such as strenuous exercise, and there were no differences if the subject was riding a bicycle, or being transported in public transportation, made no difference. The report mentioned that women and subjects over 60 years of age or older, and patients with diabetes were at higher risk for the onset of an infarction when compared with men, non diabetic or subjects younger 60 years old, after the exposure to traffic. Stress, air pollution, and noise, as well as, individual The exclusive license for this PDF is limited to personal website use only. No part of this digital document may be reproduced, stored in a retrieval system or transmitted commercially in any form or by any means. The publisher has taken reasonable care in the preparation of this digital document, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein. This digital document is sold with the clear understanding that the publisher is not engaged in rendering legal, medical or any other professional services.
    Traffic Related Air Pollution and Internal Combustion Engines, 1 edited by Sergey Demidov and Jacques Bonnet, 01/2009: chapter 1: pages 1-28; Nova Publishers., ISBN: 978-1-60741-145-1
  • [Show abstract] [Hide abstract]
    ABSTRACT: This review summarizes the effects of more than 20 metals that, research has indicated, may influence male reproductive health. Though males lack an apparent, easily measurable reproductive cycle, progress has been made in evaluating tests to identify chemical hazards and estimate reproductive health risks. Some agents discussed in this review are well known to have potential toxic effects on the male reproductive system, whereas some are not so well established in toxicology. This review attempts to cover most of the known toxicants and their effects on male fertility. The literature suggests a need for further research in those chemicals that are reactive and capable of covalent interactions in biological systems, as well as those defined as mutagens and/or carcinogens, to cause aneuploidy or other chromosomal aberrations, affect sperm motility in vitro, share hormonal activity or affect hormone action, and those that act directly or indirectly to affect the hypothalamo-pituitary-gonadal axis.
    Drug and Chemical Toxicology 09/2012; · 1.29 Impact Factor