Article

Neo-capsule tissue reactions in metal-on-metal hip arthroplasty.

Department of Orthopaedic Surgery, University Hospital Carl Gustav Carus, Dresden, Germany.
Acta Orthopaedica (impact factor: 2.17). 05/2007; 78(2):211-20. DOI:10.1080/17453670710013708 pp.211-20
Source: PubMed

ABSTRACT Modern-generation metal-on-metal articulations have a high wear resistance and may therefore be able to improve the long-term performance of artificial joints. However, the biological effects are still under debate. This study was undertaken to review the histopathological changes in neo-capsule tissues of different metal-on-metal hip arthroplasties.
Neo-capsule tissue samples from 46 hips with modern second-generation metal-on-metal articulations (39 hip resurfacings and 7 non-cemented total hip replacements) with a variety of failure mechanisms were examined histopathologically and immunohistochemically.
A distinct lymphocytic infiltration was found in all cases with in situ times of more than 7 months, consisting of CD20-positive B-lymphocytes and CD3-positive T-lymphocytes and sometimes thinly distributed CD138-positive plasma cells without dominant T-cell or plasma cell infiltrates.
This distinct lymphocytic infiltration has not been reported in tissue analyses of metal- or ceramic-on-polyethylene hip replacements, and may therefore be considered to be a characteristic histological pattern of tissue reactions on metal particles and/or ions around metal-on-metal bearings.

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Keywords

39 hip resurfacings
 
7 non-cemented total hip replacements
 
CD138-positive plasma cells
 
CD20-positive B-lymphocytes
 
ceramic-on-polyethylene hip replacements
 
characteristic histological pattern
 
different metal-on-metal hip arthroplasties
 
distinct lymphocytic infiltration
 
dominant T-cell
 
failure mechanisms
 
histopathological changes
 
histopathologically
 
immunohistochemically
 
ions
 
modern second-generation metal-on-metal articulations
 
Modern-generation metal-on-metal articulations
 
neo-capsule tissues
 
situ times
 
tissue reactions
 
wear resistance
 

Wolf-Christoph Witzleb