Alcohol intake and breast cancer risk among young women

Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, Oslo, Norway.
Breast Cancer Research and Treatment (Impact Factor: 3.94). 04/2008; 108(1):113-20. DOI: 10.1007/s10549-007-9578-8
Source: PubMed


Alcohol intake has been consistently associated with breast cancer risk, but the importance of timing of intake and the impact of beverage type are unclear.
We evaluated whether early, lifetime or recent alcohol intake was associated with breast cancer risk, and whether risk varied by type of alcoholic drinks in 1,728 newly diagnosed population-based breast cancer patients and 435 control subjects aged 20-49 years. We used multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) as measures of the relative risk of breast cancer associated with intake of alcoholic drinks.
Intake of alcoholic drinks during the recent five year period before the breast cancer diagnosis was associated with increased breast cancer risk (P (trend) = 0.04). Intake of two or more alcoholic drinks per day during this five year period was associated with an 82% increase in breast cancer risk relative to never drinkers (OR = 1.82, 95% CI = 1.01-3.28). No risk increase was observed for alcohol intake at ages 15-20 years or for lifetime alcohol intake. Risk did not vary by type of alcohol consumed.
Our results suggest that recent alcohol consumption may be associated with increased breast cancer risk in young women.

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    • "The number of articles identified by the electronic search is given in Fig. 1. Fourteen full-text articles on breast cancer (Adami et al., 1988; Colditz, 1993; Herrinton et al., 1993; Freudenheim et al., 1995; Longnecker et al., 1995a,b; Swanson et al., 1997; Männistö et al., 2000; Tjonneland et al., 2004; Terry et al., 2006; Berstad et al., 2008; Chen et al., 2011; Chandran et al., 2013; Weaver et al., 2013), seven on UADT (Zheng et al., 1990; Lopez-Abente et al., 1992; Launoy et al., 1997; Franceschi et al., 2000; Thygesen et al., 2007; Weikert et al., 2009; Jayasekara et al., 2015), six on colorectal cancer (Kune et al., 1987; Freudenheim et al., 1990; Riboli et al., 1991; Lieberman et al., 2003; Ferrari et al., 2007; Thygesen et al., 2008) and one on both UADT and colorectal cancer (Benedetti et al., 2009) were selected after excluding the others based on their title or abstract. "
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    ABSTRACT: Aims: Cancers of female breast, upper aero-digestive tract (UADT) (oral cavity, pharynx, larynx, oesophagus) and colorectum are causally related to alcohol consumption. Although alcohol consumption is likely to vary during life, the few studies that have explicitly measured lifetime consumption or intake over time have not been summarised. We therefore conducted a systematic review and meta-analysis. Methods: Studies were identified by searching the Medline, CINAHL (Cumulative Index to Nursing and Allied Health Literature) and Scopus databases through January 2015 using broad search criteria. Studies reporting relative risks (RR) for quantitatively defined categories of alcohol consumption over time for breast, UADT or colorectal cancer were eligible. A two-stage random-effects meta-analysis was used to estimate a dose-response relationship between alcohol intake and each cancer site. RRs were also calculated for the highest relative to the lowest intake category. Results: Sixteen articles for breast, 16 for UADT and 7 for colorectal cancer met the eligibility criteria. We observed a weak non-linear dose-response relationship for breast cancer and positive linear dose-response relationships for UADT and colorectal cancer. The pooled RRs were 1.28 (95% confidence interval, CI: 1.07, 1.52) for breast, 2.83 (95% CI: 1.73, 4.62) for UADT, 4.84 (95% CI: 2.51, 9.32) for oral cavity and pharynx, 2.25 (95% CI: 1.49, 3.42) for larynx, 6.71 (95% CI: 4.21, 10.70) for oesophageal and 1.49 (95% CI: 1.27, 1.74) for colorectal cancer. Conclusion: Our findings confirm dose-dependent associations between long-term alcohol intake and breast, UADT and colorectal cancer.
    Alcohol and Alcoholism 09/2015; DOI:10.1093/alcalc/agv110 · 2.89 Impact Factor
    • "Height, weight, age at menarche, parity, current oral contraceptive use, current use of hormone replacement therapy, menopausal status, smoking status and education. Berstad et al. (2008) Case–control 1728/435 Recent alcohol intake (average intake in the 5 years before the alcohol reference date) Highest category versus lowest category of alcohol consumption (more than 14 alcoholic drinks per week versus never drinkers) OR ¼ 1.82 (1.01–3.28) Age, race, education, first-degree breast cancer family history, age at menarche, age at first fullterm pregnancy, parity, breast- feeding. "
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    ABSTRACT: Breast cancer occurs as a result between genes–diet interactions. Concerning diet, only alcohol is widely recognized for being most consistently associated with breast cancer risk. The purpose of this review is to report through a systematic way the current scientific evidence relating breast cancer and diet, through original-research studies published in English language during the last decade, assessing the consumption of specific foodstuffs/food-nutrients in relation to the disease. The available literature suggests that soy food intake seems to be inversely associated with the disease, while no association seems to be reported for dietary carbohydrates and dietary fiber intake. The consumption of dietary fat, is probably suggestive of an increase in breast cancer risk, while studies evaluating the role of fruit/vegetable, meat as well as dietary patterns and breast cancer risk, provide inconsistent results. Diet seems to be modestly associated with the disease, highlighting the need for more studies to be conducted.
    International Journal of Food Sciences and Nutrition 09/2014; 66(1). DOI:10.3109/09637486.2014.950207 · 1.21 Impact Factor
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    • "Another difficulty of case-control studies is the time required to consider exposure factors. Some studies [22, 33] considered exposure factors over 1 year. In the present study, we adopted 6 months preceding the interview to minimize memory bias. "
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    ABSTRACT: Patterns of physical activity, body composition, and breastfeeding are closely related to health and are influenced by environmental, economic, and social factors. With the increase of sedentary lifestyle and overweight, many chronic diseases have also increased, including cancer. Breast cancer is the most common cancer in women worldwide, and the knowledge of its risk and protective factors is important to the adoption of primary prevention strategies. We aimed to investigate some risk and protective factors for breast cancer among women from Midwest Brazil. It is a case-control study of outpatient basis, carried out with 93 breast cancer cases and 186 controls. Socioeconomic, gynecological, anthropometric, and lifestyle variables were collected, and odds ratios (ORs) values were estimated (significance level, 5%; confidence interval (CI), 95%). Per capita income equal to or lower than 1/2 Brazilian minimum wage (OR = 1.88; CI = 1.06-3.29), residence in rural area (OR = 4.93; CI = 1.65-14.73), and presence of family history of breast cancer (OR = 5.38; CI = 1.46-19.93) are risk factors for breast cancer. In turn, physical activity (past 6 months) (OR = 0.23; CI = 0.10-0.55) and leisure physical activity at 20 years old (OR = 0.13; CI = 0.03-0.54) are protective factors for the disease in women who live in Midwest of Brazil.
    Journal of Environmental and Public Health 05/2012; 2012:356851. DOI:10.1155/2012/356851
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