We examined the effects of Applephenon and ascorbic acid administration on physical fatigue.
In a double-blinded, placebo-controlled, three-way crossover design, 18 healthy volunteers were randomized to oral Applephenon (1200 mg/d), ascorbic acid (1000 mg/d), or placebo for 8 d. The fatigue-inducing physical task consisted of workload trials on a bicycle ergometer at fixed workloads for 2 h on two occasions. During the test, subjects performed non-workload trials with maximum velocity for 10 s at 30 min (30-min trial) after the start of the test and 30 min before the end of the test (210-min trial).
The change in maximum velocity between the 30- and 210-min trials was higher in the group given Applephenon than in the group given placebo; ascorbic acid had no effect.
These results suggest that Applephenon attenuates physical fatigue, whereas ascorbic acid does not.
"Eighteen healthy male volunteers [30.1 ± 10.8 years of age
(mean ± SD)] were enrolled in this study. Current smokers,
participants having a history of medical illness, taking chronic medications or
supplemental vitamins, or with a body weight less than 40 kg were excluded from
the study based on our previous studies [11-15]. The study protocol was approved by the Ethics Committee of Osaka City
University, and all the participants provided written, informed consent. "
[Show abstract][Hide abstract] ABSTRACT: BACKGROUND: Fatigue can be classified as mental and physical depending on its cause, and each type of fatigue has a multi-factorial nature. We examined the effect of mental fatigue on the central nervous system using electroencephalography (EEG) in eighteen healthy male volunteers.Methods
After enrollment, subjects were randomly assigned to two groups in a single-blinded, crossover fashion to perform two types of mental fatigue-inducing experiments. Each experiment consisted of four 30-min fatigue-inducing 0- or 2-back test sessions and two evaluation sessions performed just before and after the fatigue-inducing sessions. During the evaluation session, the participants were assessed using EEG. Eleven electrodes were attached to the head skin, from positions F3, Fz, F4, C3, Cz, C4, P3, Pz, P4, O1, and O2.ResultsIn the 2-back test, the beta power density on the Pz electrode and the alpha power densities on the P3 and O2 electrodes were decreased, and the theta power density on the Cz electrode was increased after the fatigue-inducing mental task sessions. In the 0-back test, no electrodes were altered after the fatigue-inducing sessions.Conclusions
Different types of mental fatigue produced different kinds of alterations of the spontaneous EEG variables. Our findings provide new perspectives on the neural mechanisms underlying mental fatigue.
"Seventeen healthy male volunteers [29.4±10.7 years of age (mean ± SD); age range, 21 to 55 years of age] were enrolled in this study (Table 1). Participants having a history of medical illness, taking chronic medications or supplemental vitamins, current smokers, or those with a body weight less than 40 kg were excluded based on our previous studies , –. The general health of each participant was also assessed by physical examination by a medical doctor. "
[Show abstract][Hide abstract] ABSTRACT: Fatigue is a common problem in modern society. We attempted to identify moderate- to long-term fatigue-related alterations in the central nervous system using cognitive tasks and electroencephalography (EEG) measures. The study group consisted of 17 healthy male participants. After saliva samples were collected to measure copy number of human herpesvirus (HHV)-6 DNA to assess the level of moderate- to long-term fatigue, subjects were evaluated using EEG, with their eyes open for 2 min, then closed for 1 min sitting quietly. Thereafter, they completed cognitive task trials to evaluate simple selective attention for 3 min (Task 1) and conflict-controlling selective attention for 6 min (Task 2, which included Stroop trials). The percent error of Task 2 for Stroop trials was positively associated with the copy number of saliva HHV-6 DNA, although the simple selective attention measures in Task 1 did not differ significantly. EEG power densities (especially the alpha power density) during the eye-closed condition were negatively associated with the saliva HHV-6 DNA level. Impaired high-level information processing such as that required for conflict-controlling selective attention in the central nervous system may be a characteristic feature of moderate- to long-term fatigue.
PLoS ONE 04/2012; 7(4):e34774. DOI:10.1371/journal.pone.0034774 · 3.23 Impact Factor
"Although the pharmacological effect of vitamin C is known to last 4-6 hours (9), our data demonstrate vitamin C injection to be effective a day after intervention as well as at 2 hours after intervention. Previous studies of vitamin C treatment for fatigue have led to disparate results: in some studies, treatment with vitamin C improved fatigue significantly [12,13]; in others, the treatment proved ineffective [14-18]. One trial showed that regular vitamin C infusion reduced fatigue in inpatients with chronic fatigue syndrome . "
[Show abstract][Hide abstract] ABSTRACT: Studies of the efficacy of vitamin C treatment for fatigue have yielded inconsistent results. One of the reasons for this inconsistency could be the difference in delivery routes. Therefore, we planned a clinical trial with intravenous vitamin C administration.
We evaluated the effect of intravenous vitamin C on fatigue in office workers. A group of 141 healthy volunteers, aged 20 to 49 years participated in this randomized, double-blind, controlled clinical trial. The trial group received 10 grams of vitamin C with normal saline intravenously, while the placebo group received normal saline only. Since vitamin C is a well-known antioxidant, oxidative stress was measured. Fatigue score, oxidative stress, and plasma vitamin C levels were measured before intervention, and again two hours and one day after intervention. Adverse events were monitored.
The fatigue scores measured at two hours after intervention and one day after intervention were significantly different between the two groups (p = 0.004); fatigue scores decreased in the vitamin C group after two hours and remained lower for one day. Trial also led to higher plasma vitamin C levels and lower oxidative stress compared to the placebo group (p < 0.001, p < 0.001, respectively). When data analysis was refined by dividing each group into high-baseline and low-baseline subgroups, it was observed that fatigue was reduced in the lower baseline vitamin C level group after two hours and after one day (p = 0.004). The same did not hold for the higher baseline group (p = 0.206).
Thus, intravenous vitamin C reduced fatigue at two hours, and the effect persisted for one day. There were no significant differences in adverse events between two groups. High dose intravenous vitamin C proved to be safe and effective against fatigue in this study.
The clinical trial registration of this trial is http://ClinicalTrials.govNCT00633581.
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