Article

Intestinal innate immunity and the pathogenesis of Salmonella enteritis.

Mucosal Immunology Laboratory, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Immunologic Research (impact factor: 3.03). 02/2007; 37(1):61-78. pp.61-78
Source: PubMed

ABSTRACT Acute gastroenteritis caused by Salmonella typhimurium infection is a clinical problem with significant public health impact. The availability of several experimental models of this condition has allowed detailed investigation of the cellular and molecular interactions involved in its pathogenesis. Such studies have shed light on the roles played by bacterial virulence factors and host innate immune mechanisms in the development of intestinal inflammation.

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Keywords

Acute gastroenteritis
 
bacterial virulence factors
 
clinical problem
 
host innate immune mechanisms
 
intestinal inflammation
 
molecular interactions
 

Chittur V Srikanth