Heterotrimeric G Protein Signaling in Filamentous Fungi *

Department of Plant Pathology and Microbiology, University of California, Riverside, California 92521, USA.
Annual Review of Microbiology (Impact Factor: 13.02). 02/2007; 61(1):423-52. DOI: 10.1146/annurev.micro.61.080706.093432
Source: PubMed

ABSTRACT Filamentous fungi are multicellular eukaryotic organisms known for nutrient recycling as well as for antibiotic and food production. This group of organisms also contains the most devastating plant pathogens and several important human pathogens. Since the first report of heterotrimeric G proteins in filamentous fungi in 1993, it has been demonstrated that G proteins are essential for growth, asexual and sexual development, and virulence in both animal and plant pathogenic filamentous species. Numerous G protein subunit and G protein-coupled receptor genes have been identified, many from whole-genome sequences. Several regulatory pathways have now been delineated, including those for nutrient sensing, pheromone response and mating, and pathogenesis. This review provides a comparative analysis of G protein pathways in several filamentous species, with discussion of both unifying themes and important unique signaling paradigms.

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Available from: Gyungsoon Park, Sep 11, 2014
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    Plant Pathology 08/2014; 64(3). DOI:10.1111/ppa.12287 · 2.97 Impact Factor
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    • "The opisthokonts have a diverse but conserved repertoire of G alpha proteins. Fungi have four distinct paralogs (GPA-1 to 4) present in Ascomycota, Basidiomycota, Mucoromycotina, and Chytridiomycetes (families reviewed in Li et al. 2007) and therefore were most likely present in the fungal ancestor. Holozoa also have four ancient paralogs, Gas, Gaq/12/13, Gai/o, and Gav (described for Metazoa in Oka et al. 2009). "
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