Blueprint for imaging in biomedical research

Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Radiology (Impact Factor: 6.21). 08/2007; 244(1):12-27. DOI: 10.1148/radiol.2441070058
Source: PubMed
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    ABSTRACT: The role of radiology in biomedical research has changed drastically during the last 10 years. It used to be a science with two main lines, namely technical development and clinical applications. There was an awareness of the need for more cost-benefit studies of the higher states of the Thornbury scale (Thornbury 1994). However, there were rarely any such studies performed and this lack of scientific efforts was probably explained by the complex biases of treatment and multiple sociological factors on the outcome of imaging examinations.
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    ABSTRACT: Nanoparticles (NP) are structures comprising from some hundred to some thousand atoms. Owing to their size (1 to 100nanometres), the physical and chemical properties of these nano-objects differ from those of classical materials. They cover a wide development area, which includes medical research: they can be classified into two major groups, organic NP (liposomes, polymers NP, carbon nanotubes, fullerenes) and inorganic NP (quantum dots, magnetic NP, Raman probes). NP can be conceived to act as a drug delivery system (therapeutic), imaging probe (diagnostic) or both (theranostic). We report recent data from scientific literature and describe main NP within medical area, their state of development, and the limited knowledge of their toxicity in human being.
    Medecine Nucleaire 06/2010; 34(6):370-376. DOI:10.1016/j.mednuc.2010.03.003 · 0.16 Impact Factor
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    ABSTRACT: A 3T MR scanner was used to investigate the relationship between the alteration of bile duct lesions and the hepatic metabolic changes in hamsters infected with Opisthorchis viverrini by using 3T MRI and (1)H MR spectroscopy. Animals were divided into control and infected groups. Five normal hamsters were used as control; fifty-five hamsters were infected with O. viverrini to induce bile duct lesions and hepatic metabolic changes. T2-weighted image sequence in three orthogonal planes were conducted by MRI scans. Single-voxel (1)H MRS was performed to obtain the relative choline-to-lipid ratios. The livers and bile ducts were excised for the histologic examination. The progression of bile duct changes by histology and metabolic changes in O. viverrini infected hamsters were co-investigated. In the O. viverrini-infected group, the T2-weighted images revealed the time-dependent intra- and extra-hepatic duct dilatations in the liver. The mean (±SD) choline-to-lipid ratios were 0.11±0.035 in the control group, whereas the ratio in the infected group increased significantly with the progression of time. Histologic grading of hepatic inflammation and fibrosis were correlated well with the MRI grading (Spearman rank correlation test; r=0.746 and p<0.001). The control group showed no dilatation of the bile ducts and showed normal liver patterns. Noninvasive technique, MRI and (1)H MRS can demonstrated and applied to evaluate not only the inflammation-related fibrosis in the small bile ducts but also the metabolic changes in the liver induced by O. viverrini infection. A significant increase in the choline-to-lipids ratios were observed in parallel with the time-course of infection. O. viverrini infected in human is detected by stool examination. Hepatobiliary morbidity is detected and followed up by ultrasonography. MRI and MRS can be used in conjunction with ultrasonography for evaluation of progression of the disease.
    Magnetic Resonance Imaging 07/2013; DOI:10.1016/j.mri.2013.05.008 · 2.02 Impact Factor