Prevalence of dementia in Chamorros on Guam - Relationship to age, gender, education, and APOE
ABSTRACT To estimate the prevalence of dementia and its clinical subtypes among Chamorros on Guam aged 65 years or older and to examine associations with age, gender, education, and APOE genotype.
Chamorros, the indigenous people of Guam, had a high incidence of ALS and parkinsonism-dementia complex (PDC), in the 1950s. Over the next 50 years, ALS incidence declined markedly, but PDC only slightly. The prevalence of late life dementia in Chamorros and its relationship to ALS/PDC are unknown.
Island-wide population-based survey of Chamorros aged 65 years or older as of January 1, 2003. Two-stage assessment: cognitive and motor screening, followed by neurologic and psychometric evaluation. Data were reviewed at consensus conference to make clinical diagnoses.
Of 2,789 Chamorros aged 65 years or older, 73% were enrolled; 27% declined participation, died before contact or screening, or moved off Guam. The point prevalence of all-cause dementia on February 1, 2004, was 12.2%. Prevalence data for subtypes were as follows: Guam dementia (clinically equivalent to AD), 8.8%; PDC, 1.5%; pure vascular dementia, 1.3%; other, 0.6%. The prevalence of dementia rose exponentially with age. Low education was significantly associated with dementia, but gender was not. There was a trend toward higher PDC prevalence among men. The APOE epsilon4 allele was not associated with dementia.
The prevalence of dementia among elderly Chamorros is relatively high. Guam dementia is the most common diagnosis and exceeds parkinsonism-dementia complex. Age and low education are strongly associated with dementia, but gender and APOE epsilon4 are not. Incidence studies will allow risk factors for dementia to be clarified.
Article: Global issueNeurology 10/2007; 69(17):1644-1644. DOI:10.1212/01.wnl.0000289090.14598.07 · 8.30 Impact Factor
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ABSTRACT: Resumen Se llevó a cabo una investigación de la prevalencia institucional de demencias en un hogar de ancianos gubernamental ubicado en la localidad de Ituzaingó de la provincia de Buenos Aires, durante el período 2002-2003. Se obtuvo una muestra estratificada al azar de 210 sujetos mayores de 60 años de ambos sexos. Entre ellos 64 sujetos cumplían con los criterios diagnósticos de demencia según el DSM-IV y el ICD-10. La prevalencia institucional de demencias obtenida fue de 27.73%. Abstract Institutional Prevalence Dementia Study at a Retirement Home in Buenos Aires province. We investigated the institutional prevalence of dementias in a governmental retirement home, located in Ituzaingó at Buenos Aires province, during the 2002-2003 periods. A stratified randomized sampling of 210 elder residents aged 60 years and older of both genders was obtained. Among these, 64 met the dementia diagnostic criteria according to DSM-IV and ICD-10. The institutional prevalence of dementia was 27.73%.Revista Neurologica Argentina 01/2009;