Visual-perceptual abilities in healthy controls, depressed patients, and schizophrenia patients

Université de Lyon, Lyon, F-69003, France.
Brain and Cognition (Impact Factor: 2.68). 09/2007; 64(3):257-64. DOI: 10.1016/j.bandc.2007.03.008
Source: PubMed

ABSTRACT Previous studies have suggested a right hemineglect in schizophrenia, however few assessed possible visual-perceptual implication in this lateralized anomaly. A manual line bisection without (i.e., lines presented on their own) or with a local cueing paradigm (i.e., a number placed at one or both ends of the line) and the Motor-free Visual Perceptual Test-Vertical format (MVPT-V) were used to assess the visual-perceptual abilities of healthy controls, schizophrenia and depressed patients. Whereas healthy controls and depressed patients showed a non-significant leftward bias in manual line bisection, schizophrenia patients bisected significantly to the left of the true centre of the line. Interestingly, the pattern of performances in response to the local cueing paradigm was similar in depressed and schizophrenia patients such that both groups demonstrated a significant change in their bisection performance only in response to a cue placed at the right extremity of the line (control performance was modified by cues at either end of the line). Finally, in the MVPT-V, schizophrenia patients were impaired relative to the other two groups, especially in the spatial working memory and visual closure categories. These results suggest that: 1/a deficit towards the right hemifield, consistent with a mild form of right hemineglect, can be observed in schizophrenia; 2/lateralized anomalies could also be observed in depression using an appropriate tool such as manual line bisection; 3/performances in the MVPT-V suggested that a simple visual-perceptual deficit could not explain the lateralized anomaly observed in the manual line bisection, as it is the case in the hemineglect syndrome.

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Available from: James Danckert, Apr 02, 2015
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    • "When gross motor activation is minimized, and scanning eye movements are disallowed by tachistoscopic presentation, the effect size (Cohen's d-statistic; Cooper and Hedges, 1994) of pseudoneglect is tripled relative to that found using manual line bisection procedures (d = − 1.32 versus − 0.40, respectively; Jewell and McCourt, 2000). In addition, most of the prior studies tested only a modest sample of patients: N = 24 (Mather et al., 1990); N = 10 (Barnett, 2006); N = 8 (Michel et al., 2007); and N = 10 (Cavezian et al., 2007). In the largest study to date, Zivotofsky et al. (2007) report data from 45 schizophrenic patients, but the lack of a control group makes interpretation of their results problematic. "
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    • "Future studies may test the accuracy of prebisected lines in order to examine the perceptual component in these patients. Most of the previous studies either did not assess the association of the psychotic symptoms and hemispheric asymmetry or found no correlation (Cavé zian et al., 2007; Michel et al., 2007; Tian et al., 2011). This study addressed an association between the degree of bisection error in the right hemispace and the severity of the negative symptoms. "
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    ABSTRACT: Visuospatial attentional asymmetry has been investigated by the line bisection task in patients with schizophrenia, however, those studies are in small number and the results are controversial. The present study aimed to investigate hemispatial neglect in patients with schizophrenia (n=30), their healthy siblings (n=30) and healthy individuals (n=24) by a computerized version of the line bisection task. Deviation from the midline for both hemispaces (mean bisection error-MBE) were calculated and the effects of both hand and line length were controlled. Repeated measures ANOVA yielded a significant hemispace effect for the MBE scores, but no group or group×hemispace interaction effect, i.e., all three groups were inclined to a leftward bias in the left and a rightward bias in the right hemispace. MBEs were significantly different from "zero" only for the right hemispace in siblings and for the left hemispace in controls. Negative symptoms were significantly correlated with the bisection errors in the right hemispace. The results of the present study do not support aberrant hemispheric asymmetry, but bigger bisection errors in schizophrenia.
    Psychiatry Research 05/2012; 200(2-3). DOI:10.1016/j.psychres.2012.04.025 · 2.68 Impact Factor
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    • "Furthermore, in the schizophrenia group, the leftward bias increased as the line length increased, which has also been observed in neglect patients. These results are line with some prior studies [4] [14] [29]. However, other studies have shown no significant differences in bisection performance between schizophrenia patients and controls [3] [19] [20]. "
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    ABSTRACT: Many studies of hemispatial neglect patients have indicated that spatial attention processes operate similarly in visual space and number space. However, some studies have indicated a dissociation of processing between visual line bisection and mental number bisection. A number of investigations have suggested that schizophrenic patients show a mild right pseudo-neglect on visual line bisection tasks. The present study was designed to determine if a functional link exists between performance of visual line and number line bisection in schizophrenic patients. Groups of 40 schizophrenic patients and 40 controls performed each bisection task. In the visual line bisection task, schizophrenic patients showed a significant leftward bias relative to the healthy controls for 9 different line lengths. No significant difference in bias was found between the 2 groups on the mental line bisection task. These results indicated that schizophrenic patients may exhibit attention deficit with respect to visual space but not number space, suggestive of the dissociation of processing between visual line bisection and mental number line bisection. These results provide more insight into the correlation between the visual line and number bisection tasks in schizophrenic patients.
    Neuroscience Letters 03/2011; 491(3):192-5. DOI:10.1016/j.neulet.2011.01.034 · 2.06 Impact Factor
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