Visual-perceptual abilities in healthy controls, depressed patients, and schizophrenia patients.

Université de Lyon, Lyon, F-69003, France.
Brain and Cognition (Impact Factor: 2.68). 09/2007; 64(3):257-64. DOI: 10.1016/j.bandc.2007.03.008
Source: PubMed

ABSTRACT Previous studies have suggested a right hemineglect in schizophrenia, however few assessed possible visual-perceptual implication in this lateralized anomaly. A manual line bisection without (i.e., lines presented on their own) or with a local cueing paradigm (i.e., a number placed at one or both ends of the line) and the Motor-free Visual Perceptual Test-Vertical format (MVPT-V) were used to assess the visual-perceptual abilities of healthy controls, schizophrenia and depressed patients. Whereas healthy controls and depressed patients showed a non-significant leftward bias in manual line bisection, schizophrenia patients bisected significantly to the left of the true centre of the line. Interestingly, the pattern of performances in response to the local cueing paradigm was similar in depressed and schizophrenia patients such that both groups demonstrated a significant change in their bisection performance only in response to a cue placed at the right extremity of the line (control performance was modified by cues at either end of the line). Finally, in the MVPT-V, schizophrenia patients were impaired relative to the other two groups, especially in the spatial working memory and visual closure categories. These results suggest that: 1/a deficit towards the right hemifield, consistent with a mild form of right hemineglect, can be observed in schizophrenia; 2/lateralized anomalies could also be observed in depression using an appropriate tool such as manual line bisection; 3/performances in the MVPT-V suggested that a simple visual-perceptual deficit could not explain the lateralized anomaly observed in the manual line bisection, as it is the case in the hemineglect syndrome.

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Available from: James Danckert, Apr 02, 2015
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    • "When gross motor activation is minimized, and scanning eye movements are disallowed by tachistoscopic presentation, the effect size (Cohen's d-statistic; Cooper and Hedges, 1994) of pseudoneglect is tripled relative to that found using manual line bisection procedures (d = − 1.32 versus − 0.40, respectively; Jewell and McCourt, 2000). In addition, most of the prior studies tested only a modest sample of patients: N = 24 (Mather et al., 1990); N = 10 (Barnett, 2006); N = 8 (Michel et al., 2007); and N = 10 (Cavezian et al., 2007). In the largest study to date, Zivotofsky et al. (2007) report data from 45 schizophrenic patients, but the lack of a control group makes interpretation of their results problematic. "
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    • "Future studies may test the accuracy of prebisected lines in order to examine the perceptual component in these patients. Most of the previous studies either did not assess the association of the psychotic symptoms and hemispheric asymmetry or found no correlation (Cavé zian et al., 2007; Michel et al., 2007; Tian et al., 2011). This study addressed an association between the degree of bisection error in the right hemispace and the severity of the negative symptoms. "
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    ABSTRACT: Visuospatial attentional asymmetry has been investigated by the line bisection task in patients with schizophrenia, however, those studies are in small number and the results are controversial. The present study aimed to investigate hemispatial neglect in patients with schizophrenia (n=30), their healthy siblings (n=30) and healthy individuals (n=24) by a computerized version of the line bisection task. Deviation from the midline for both hemispaces (mean bisection error-MBE) were calculated and the effects of both hand and line length were controlled. Repeated measures ANOVA yielded a significant hemispace effect for the MBE scores, but no group or group×hemispace interaction effect, i.e., all three groups were inclined to a leftward bias in the left and a rightward bias in the right hemispace. MBEs were significantly different from "zero" only for the right hemispace in siblings and for the left hemispace in controls. Negative symptoms were significantly correlated with the bisection errors in the right hemispace. The results of the present study do not support aberrant hemispheric asymmetry, but bigger bisection errors in schizophrenia.
    Psychiatry Research 05/2012; 200(2-3). DOI:10.1016/j.psychres.2012.04.025 · 2.68 Impact Factor
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    • "Spatial deficits have been shown to correlate with the progression of the disease, functional outcome and quality of life (Langdon & Ward, 2008; Lysaker et al., 2007). Stabilized patients have repeatedly demonstrated deficits in attention allocation (Amado et al., 2009; Kebir, Ben Azouz, Amado, & Tabbane, 2008; Posner, Early, Reiman, Pardo, & Dhawan, 1988) supporting the notion of a proposed schizophrenic 'pseudo-hemineglect' (Cavezian et al., 2007; Posner et al., 1988). Impaired visuo-spatial functioning has been observed in spatial delayed-response tasks (Keefe et al., 1995; Park & Holzman, 1992), including memory-guided saccade paradigms (Calkins & Iacono, 2000; Gooding & Basso, 2008; Landgraf, Amado, Bourdel, Leonardi, & Krebs, 2008) and spatial span tasks (Cannon et al., 2000; Perry et al., 2001). "
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    ABSTRACT: Psychotic symptoms in schizophrenia patients encompass the difficulty to distinguish between the respective points of view of self and others. The capacity to adopt and switch between different perspectives is, however, fundamental for ego- and allocentric spatial referencing. We tested whether schizophrenia patients are able to adopt and maintain a non-egocentric point of view in a complex visual environment. Twenty-four chronic schizophrenic outpatients (11 females) and 25 controls matched for age, gender, years of education and handedness were recruited from a population-based sample. In a virtual environment, participants had to make a decision as to which of two trash cans was closest to themselves (viewer-centered, egocentric), to a ball (object-centered, unstable allocentric), or to a palace (landmark-centered, stable allocentric). Main outcome measures were reaction time, error rate, learning rate and local task switch cost. While egocentric reaction time was preserved, patients showed an increased reaction time in both allocentric referencing conditions (stable and unstable) and an overall increased error rate. Switch cost was diminished in patients when changing from the egocentric to the landmark-centered condition and elevated when changing from the landmark-centered to the egocentric condition. The results imply that schizophrenia patients' adoption of an egocentric perspective is preserved. However, adopting an allocentric point of view and switching between egocentric and landmark-centered perspectives are impaired. Perturbations in non-egocentric referencing and transferring efficiently between different referential systems might contribute to altered personal and social world comprehension in schizophrenia.
    Neuropsychologia 08/2010; 48(10):2922-30. DOI:10.1016/j.neuropsychologia.2010.05.034 · 3.45 Impact Factor
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