[Establishment of an experimental animal model with alveolar bone defect by surgery in rats].
ABSTRACT To establish an animal model for experimental study of orthodontic treatment of alveolar bone defect and other relative research.
The experiment was carried out on forty SPF female Wistar rats,which were 6 weeks old. With the rats anaesthetized, one side of the alveolar bone in the maxillary first molar of the rats was removed partly. The defects were filled with Bio-glass. The tissue slices from the defects were observed under light microscope 2 weeks after surgery.
Only one of the forty rats was infected after operation, and the survival rate was 97.5%. The wounds of the survived rats healed well, and new bone was found around the Bio-glass 2 weeks after operation.
Animal model of alveolar bone defect established by surgery is simple and reliable, which can be used for further studies. Supported by National Natural Science Foundation of Shandong Province (Grant No.Y2004C13) and Medical Science and Technology Enhancement Award Project of Shangdong Province (Grant No.2005H2038).