Article

[Establishment of an experimental animal model with alveolar bone defect by surgery in rats].

Department of Orthodontics, School of Stomatology, Shandong University. Jinan 250012, Shandong Province, China.
Shanghai kou qiang yi xue = Shanghai journal of stomatology 01/2007; 15(6):645-8. pp.645-8
Source: PubMed

ABSTRACT To establish an animal model for experimental study of orthodontic treatment of alveolar bone defect and other relative research.
The experiment was carried out on forty SPF female Wistar rats,which were 6 weeks old. With the rats anaesthetized, one side of the alveolar bone in the maxillary first molar of the rats was removed partly. The defects were filled with Bio-glass. The tissue slices from the defects were observed under light microscope 2 weeks after surgery.
Only one of the forty rats was infected after operation, and the survival rate was 97.5%. The wounds of the survived rats healed well, and new bone was found around the Bio-glass 2 weeks after operation.
Animal model of alveolar bone defect established by surgery is simple and reliable, which can be used for further studies. Supported by National Natural Science Foundation of Shandong Province (Grant No.Y2004C13) and Medical Science and Technology Enhancement Award Project of Shangdong Province (Grant No.2005H2038).

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Keywords

alveolar bone
 
animal model
 
experimental study
 
Medical Science
 
National Natural Science Foundation
 
new bone
 
orthodontic treatment
 
relative research
 
Shandong Province
 
Shangdong Province
 
survival rate
 
Technology Enhancement Award Project
 
tissue slices
 
wounds
 

Xu-Xia Wang