Article
Coupling and internal noise sustain synchronized oscillation in calcium system.
The Institute for Chemical Physics, Beijing Institute of Technology, Beijing, 100081, PR China.
Biophysical Chemistry (impact factor:
2.2).
09/2007;
129(1):23-8.
DOI:10.1016/j.bpc.2007.05.001
Source: PubMed
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Citations (0)
- Cited In (3)
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Article: Optimal spatial synchronization on scale-free networks via noisy chemical synapses.
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ABSTRACT: We show that the spatial synchronization of noise-induced excitations on scale-free networks, mediated through nonlinear chemical coupling, depends vitally on the intensity of additive noise and the coupling strength. In particular, a twofold optimization is needed for achieving maximal spatial synchrony, thus indicating the existence of an optimal noise intensity as well as an optimal coupling strength. On the other hand, the traditional linear coupling via gap junctions, while still requiring a fine-tuning of the noise intensity, does not postulate the existence of an optimal coupling strength since the synchronization increases monotonously with the increasing coupling strength. Presented results reveal inherent differences in optimal spatial synchronization evoked by chemical and electrical coupling, and could hence help to pinpoint their specific roles in networked systems.Biophysical chemistry 03/2009; 141(2-3):175-9. · 2.28 Impact Factor -
Article: Emergence of noise-induced oscillations in the central circadian pacemaker.
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ABSTRACT: Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluctuating levels of PER2 detected by bioluminescence imaging but could not generate circadian oscillations intrinsically. Inhibition of intercellular communication or cyclic-AMP signaling in SCN slices, which provide a positive feed-forward signal to drive the intracellular negative feedback loop, abolished the stochastic oscillations. Propagation of this feed-forward signal between SCN neurons then promotes quasi-circadian oscillations that arise as an emergent property of the SCN network. Experimental analysis and mathematical modeling argue that both intercellular coupling and molecular noise are required for the stochastic rhythms, providing a novel biological example of noise-induced oscillations. The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization.PLoS Biology 01/2010; 8(10):e1000513. · 11.45 Impact Factor -
Article: Correction: emergence of noise-induced oscillations in the central circadian pacemaker.
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ABSTRACT: [This corrects the article on p. e1000513 in vol. 8.].PLoS Biology 01/2010; 8(10). · 11.45 Impact Factor
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Keywords
bifurcation diagram
cross-correlation time
decreases
distinctly
increment
internal noise
non-identical subsystems
oscillatory region
similar phenomena
steady state
two non-identical oscillators synchronized
two oscillators
