Angiogenesis and vasculogenesis: inducing the growth of new blood vessels and wound healing by stimulation of bone marrow-derived progenitor cell mobilization and homing.

Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104-4283, USA.
Journal of Vascular Surgery (Impact Factor: 2.98). 07/2007; 45 Suppl A:A39-47. DOI: 10.1016/j.jvs.2007.02.068
Source: PubMed

ABSTRACT During embryonic development, the vasculature is among the first organs to form and is in charge of maintaining metabolic homeostasis by supplying oxygen and nutrients and removing waste products. As one would expect, blood vessels are critical not only for organ growth in the embryo but also for repair of wounded tissue in the adult. An imbalance in angiogenesis (a time-honored term that globally refers to the growth of new blood vessels) contributes to the pathogenesis of numerous malignant, inflammatory, ischemic, infectious, immune, and wound-healing disorders. This review focuses on the central role of the growth of new blood vessels in ischemic and diabetic wound healing and defines the most current nomenclature that describes the neovascularization process in wounds. There are now two well-defined, distinct, yet interrelated processes for the formation of postnatal new blood vessels, angiogenesis, and vasculogenesis. Reviewed are recent new data on vasculogenesis that promise to advance the field of wound healing.

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    ABSTRACT: Love "Each year in the United States, there are more than 700,000 [cases of people suffering] strokes. Stroke is the third leading cause of death in the country. And stroke causes more serious long-term disabilities than any other disease. Nearly three-quarters of all strokes occur in people over the age of 65 and the risk of having a stroke more than doubles each decade after the age of 55." (National Institutes of Neurological Disorders and Stroke, NIH, Centers for Disease Control and Prevention, 2004) INTRODUCTION In the U.S. it is estimated that 6.4 million adults have suffered a stroke and another 13 million may have experienced a "silent stroke", loss of brain cells without visible symptoms. The financial burdens associated with stroke treatment and recovery (both direct and indirect) is estimated to be $73 billion dollars for 2010. In spite of modest declining rates of strokes for the last 7 years, the prevalence of this disease continues to constitute a major source of long-term disabilities for the American public, as well as an expanding cost in health care and household budgets. Drug treatments for brain strokes are only available for patients diagnosed 1-3 hours after the onset of a clot induced stroke. With more than 90% of stroke patients falling outside of this treatment group, new treatments must be developed. Therapies that focus on salvaging and protection of brain tissue in this large group of stroke sufferers is a major focus for the medical and scientific community. One treatment that has the proven ability to salvage oxygen starved tissue is hyperbaric oxygen therapy (HBOT). HBOT has been used for more than a 100 years to increase oxygen intake in damaged or oxygen-starved tissues. By increasing atmospheric pressure around the damaged tissue and applying 100% oxygen, the total amount of oxygen in the blood and organs increases, ensuring that all cells are supplied with this life sustaining gas. Evidence of the benefits of HBOT in the treatment of stroke has been accumulating this past decade. With the improvement of imaging technology and better clinical assessment a positive effect of HBOT for stroke patients has been established. Clinical studies and reports in animal models of stroke clearly show a protective effect, as well as a strong therapeutic potential for alleviating neurological symptoms and restoring functionality, even in patients that have suffered a stroke weeks or months earlier.
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    Journal of Surgical Research 10/2014; 193(2). DOI:10.1016/j.jss.2014.10.019 · 2.12 Impact Factor


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