Long-Term Efficacy of Sublingual Immunotherapy in Patients With Perennial Rhinitis

Istanbul University, ─░stanbul, Istanbul, Turkey
The Laryngoscope (Impact Factor: 2.03). 07/2007; 117(6):965-9. DOI: 10.1097/MLG.0b013e31804f8141
Source: PubMed

ABSTRACT Sublingual immunotherapy has a documented clinical efficacy, but only a few long-term studies have been performed in people with perennial rhinitis.
The purpose of this study was to evaluate the long-term efficacy of sublingual immunotherapy.
One hundred thirty-seven patients with allergies to house dust mites were treated with sublingual house dust-mite-specific immunotherapy for 2 or 3 years and were also observed for 3 years after discontinuation of the treatment. The patients were divided into 2 groups: group A (67 patients) received active treatment for 2 years and then 1 year for placebo, and group B (70 patients) received active treatment for 3 years. The success of the treatment was evaluated with the symptom score, skin prick test results, and the nasal allergen challenge score.
According to our study results, we found a greater improvement in the 3 years of sublingual immunotherapy compared with the 2 years of sublingual immunotherapy when we looked at the comparative results of the total 6 years.
We suggest 3 years of sublingual immunotherapy for patients with perennial allergic rhinitis who require immunotherapy and do not accept the subcutaneous route of allergen administration.

  • [Show abstract] [Hide abstract]
    ABSTRACT: A technique for automatically inserting software mechanisms to detect single event upset (SEU) in distributed Ada systems is presented. SEUs may cause information corruption, leading to a change in program flow or causing a program to execute an infinite loop. Two cooperative software mechanisms for detecting the presence of these upsets are described. Automatic insertion of these mechanisms is discussed in relation to the structure of Ada software systems. A program, software modifier for upset detection (SMUD), has been written to automatically modify Ada application software and insert software upset detection mechanisms. As an example, the mechanisms have been incorporated into a system model that employs the MIL-STD-1553B communications protocol. This system model is used as a testbed for verifying that SMUD properly inserts the detection mechanisms. Ada is used for creating the simulation environment to exercise and verify the protocol. Simulation has been used to test and verify the proper functioning of the detection mechanisms. The testing methodology, a short description of the 1553B testbed, and a set of performance measures are presented
    System Sciences, 1989. Vol.II: Software Track, Proceedings of the Twenty-Second Annual Hawaii International Conference on; 02/1989
  • [Show abstract] [Hide abstract]
    ABSTRACT: A project between Fernald EMP and LANL is to field a monitor for the detection of alpha-emitting contamination on a human body. Traditional personnel monitoring for alpha emitters involves either frisking with a probe or pressing against large detectors in order to overcome the short range of alpha particles. These methods have a low alpha collection efficiency, and can miss contamination on less accessible surfaces. We have investigated the sensitivity and practicality of measuring the entire subject simultaneously using the technique of ionization monitoring. The goal is to create a booth that personnel step into quickly during egress from radiological facilities. The detection technique relies on a breeze of air passing over the subject. Alpha emission produces copious ions in the ambient air which are transported by the air current to an ion collector, resulting in a small electrical current proportional to the amount of contamination. Results indicate a conservative sensitivity of 3000 disintegrations per minute localized to one of five areas of the body in a measurement lasting less than 2 minutes
    IEEE Transactions on Nuclear Science 07/1998; DOI:10.1109/23.682691 · 1.46 Impact Factor
  • Source
    World Allergy Organization Journal 11/2009; 2(11):233-81. DOI:10.1097/WOX.0b013e3181c6c379