Article

[Current status of research on conjugates and related drug delivery systems in the treatment of cancer and other diseases].

Zakład Onkologii Doświadczalnej, Instytut Immunologii i Terapii Doświadczalnej im. L. Hirszfelda, Polska Akademia Nauk we Wrocławiu, Wrocław, Poland.
Postępy Higieny i Medycyny Doświadczalnej (Advances in Hygiene and Experimental Medicine) 02/2007; 61:350-60. pp.350-60
Source: PubMed

ABSTRACT Drug delivery systems is an umbrella term describing different types of carrier-drug and carrier-protein conjugates, liposomes, polyplexes, micelles, and hybrid types. Such systems were designed with the aim to enhance delivery and to improve the selectivity and pharmacological properties of both conventional drugs and newly developed agents. In this review the current state-of-the-art in the design of drug delivery systems is described, with particular emphasis on agents developed to deliver antitumor agents. The advantages, limitations, and disadvantages of the particular types of drug delivery systems as well as the theoretical and practical basis of their action are also highlighted here. In addition, results of preclinical and clinical studies on the most developed examples of drug delivery systems to date are summarized.

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Keywords

advantages
 
agents
 
antitumor agents
 
carrier-protein conjugates
 
clinical studies
 
conventional drugs
 
current state-of-the-art
 
developed examples
 
different types
 
disadvantages
 
drug delivery systems
 
hybrid types
 
particular types
 
pharmacological properties
 
preclinical
 
umbrella term