Phyllodes tumors (PT) are rare fibroepithelial neoplasms of the breast with unpredictable behavior. We reviewed our single institution experience with PT over 51 years to identify factors predictive of local recurrence (LR) and metastasis.
From 1954 to 2005, a total of 352 cases of PT were identified; 293 had follow-up. All available pathology slides (90%) were rereviewed for margins, borders, fibroproliferation in the surrounding breast tissue, stromal pattern, stromal cellularity, frequency of mitoses, and necrosis.
All cases occurred in women, with a median age of 42, with 203 originally categorized as benign and 90 as malignant. Median follow-up was 7.9 years. A total of 35 patients developed LR at a median of 2 years. In univariate analyses, a higher actuarial LR rate was associated with positive margins (P = .04), fibroproliferation (P = .001), and necrosis (P = .006). PT classified as malignant did not have a higher risk of LR (P = .79). Five patients developed distant disease at a median of 1.2 years. These patients constituted 71% of the seven patients who had uniformly aggressive pathologic features, including large tumor size (>or=7.0 cm), infiltrative borders, marked stromal overgrowth, marked stromal cellularity, high mitotic count, and necrosis.
Positive margins, fibroproliferation in the surrounding breast tissue, and necrosis are associated with a marked increase in LR rates. Efforts should be made to achieve negative surgical margins to reduce risk of LR. Death from PT is rare (2%), and only PT that demonstrate uniformly aggressive pathologic features seem to be associated with mortality.
"Malignant tumors can demonstrate sarcomatous behavior and metastasize hematogenously to the lungs, skeleton, heart, and liver. Because of these aggressive growth patterns, both benign and malignant lesions should be excised completely with no tissue left behind in order to prevent recurrence   . While studies have shown surgical margin status to be a principal determinant of local recurrence and disease metastasis, there are no official guidelines on how much to excise around lesions. "
[Show abstract][Hide abstract] ABSTRACT: The challenging issue for the breast surgeons is local recurrence of phyllodes tumor. The histological criteria to predict local recurrence has been a controversial issue. The objective of this study was to determine pathological parameters and surgical margins that influence outcome of local recurrence and distant metastasis in phyllodes tumor (PT).
Retrospective review between January 2003 to August 2008 at King Hussein Cancer Center-Jordan.
Forty-two female patients diagnosed as having PT were classified to benign, borderline and malignant. The medical records were reviewed in relation to the surgical management, recurrence, follow-up, the histological features of the tumor and grading of tumors based on the following histological parameters: mitotic count, stromal cellularity, stromal overgrowth, cellular pleomorphism, nuclear grade, tumor necrosis, tumor margin, and surgical margin status. All patients underwent wide local excision of the tumor or mastectomy.
Forty-two patients with PT (16 benign, 9 borderline, 17 malignant PT) were followed up for 30 months. The mean age was 39.8 years, and the average tumor size was 6.6 cm. The recurrence rate of PT in our study was 21% at a mean time of 11 months. Nine patients had local recurrence; 2 benign, 6 malignant and 1 borderline. Cellular pleomorphism had correlation with recurrence rate (P=.045). We had six patients (14%) with distant metastasis. All had malignant PT. Metastasis in PT has a relationship with histological grade (P=.02).
We conclude that patients with moderate and severe cellular pleomorphism had higher local recurrence, while metastatic PT occur more in patients with high nuclear grade.
Annals of Saudi medicine 03/2013; 33(2):162-8. DOI:10.5144/0256-4947.2013.162 · 0.49 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: In this report we have used projectivity theory to model the process of structured light scanning for 3D robot vision. The projectivity formalism is used to derive a 4 × 3 transformation matrix that converts points in the image plane into their corresponding 3D world coordinates. Calibration of the scanner consists of computing the coefficient of this matrix by showing to the system a set of lines generated by suitable object edges. We end this paper by showing how the matrix can be used to convert image pixel locations into the world coordinates of the corresponding object points using two different scanning strategies.
Robotics and Automation. Proceedings. 1987 IEEE International Conference on; 04/1987
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