A systematic review of economic analyses of pharmaceutical therapies for advanced colorectal cancer.
ABSTRACT Colorectal cancer is one of the most common causes of cancer in the Western world. New drugs in the treatment of advanced colorectal cancer, such as irinotecan and oxaliplatin, have substantially increased the cost of treatment. A systematic literature review on the cost (-effectiveness) of pharmaceutical therapies for advanced colorectal cancer was conducted, in which 13 articles were included. The main topics were: orally versus intravenously administered fluoropyrimidine, raltitrexed, irinotecan and oxaliplatin. Additional information was collected on the cost (-effectiveness) of the monoclonal antibodies, cetuximab and bevacizumab. Only five articles had taken the societal perspective, in most articles no data on quality of life was presented, and only two reported the cost per quality-adjusted life year. As only a limited amount of information is available on the cost-effectiveness of pharmaceutical therapies for advanced colorectal cancer, there is a need for more cost-effectiveness studies. These studies are preferably performed by taking a societal perspective and including quality of life outcomes.
- SourceAvailable from: Catherine Meads
Conference Paper: An overview of cost and operational effectiveness analysis (COEA)[Show abstract] [Hide abstract]
ABSTRACT: This paper contains an overview on one of the most talked about topics in the Department of Defense, the cost and operational effectiveness analysis (COEA) and discusses performance of a COEA in support of the DoD material acquisition system. The material outlines the suggested analysis approach described in today's governmental regulations and provides in detail the methodology needed to perform these studies, a requirement which has been passed down to the analysis “shops” of the military services. The paper defines the purpose and scope of the COEA and overviews the important factors and techniques needed to perform these studies. Highlighted are the planning requirements, modeling issues, and the need for various forms of verified and validated data. Discussed is the establishment of measures of merit used to distinguish the worth of the various alternatives under consideration, as well as the simulation tools used to define and evaluate the effectiveness of operations and costs in the envisioned environment. Topics covered range from those discerning the political study environment, to the techniques for presenting the analytical resultsAerospace and Electronics Conference, 1994. NAECON 1994., Proceedings of the IEEE 1994 National; 06/1994