Extended-release formulation of venlafaxine in the treatment of post-traumatic stress disorder

The Catholic University of Korea College of Medicine, Department of Psychiatry, Kangnam St. Mary's Hospital, Seoul 137-701, South Korea.
Expert Review of Neurotherapeutics (Impact Factor: 2.78). 07/2007; 7(6):603-15. DOI: 10.1586/14737175.7.6.603
Source: PubMed


There is abundant evidence for abnormalities of both norepinephrine and serotonin neurotransmitter systems in post-traumatic stress disorder (PTSD). Venlafaxine extended-release formulation (venlafaxine XR) is a serotonin and norepinephrine re-uptake inhibitor with antidepressant and anxiolytic properties relevant to the pathophysiology of PTSD. Venlafaxine XR is currently approved for the treatment of panic disorder, generalized anxiety disorder and social anxiety disorder, as well as major depression in adults, based on a number of randomized, double blind, placebo-controlled clinical trials. Limited data also demonstrate that venlafaxine XR maintains a therapeutic response for more than 6 months in these anxiety disorders. Venlafaxine XR has demonstrated short- and long-term efficacy for the treatment of PTSD in two recent randomized, double-blind, placebo-controlled clinical trials, although it has not been extensively studied for PTSD, compared with other anxiety disorders. This review focuses on the potential role of venlafaxine XR in the treatment of PTSD, based on currently available evidence.

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    • "Fortunately, there have been significant advances in both the pharmacotherapy and psychotherapy of PTSD (Pratchett et al., 2011). The selective serotonin re-uptake inhibitors (SSRIs) and the serotonin–norepinephrine re-uptake inhibitors (SNRIs) are now accepted as firstline pharmacotherapy for PTSD (Asnis et al., 2004; Ursano et al., 2004; Stein et al., 2006; Marshall et al., 2007; Pae et al., 2007). Unfortunately, up to 40% of participants in clinical trials fail to respond adequately to these agents (Rasmussen, 2006; Stein et al., 2006). "
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    • "Also, this study could not address the combinatorial impact of blockade of serotonin and norepinephrine transporters , ie, SNRIs. These drugs have shown preliminary Noradrenergic vs serotonergic IL Petrakis et al efficacy for PTSD (Davidson et al, 2006; Pae et al, 2007; Richelson, 2003). Their efficacy in AD is untested. "
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