Population genetics of familial Mediterranean fever: a review

Institute of Man, Yerevan, Armenia.
European Journal of HumanGenetics (Impact Factor: 4.23). 10/2007; 15(9):911-6. DOI: 10.1038/sj.ejhg.5201869
Source: PubMed

ABSTRACT In this review, some principal population genetic features of familial Mediterranean fever (FMF) are considered. These relate to the time and the place of founder mutations' origins, the role of ancient migrations and contacts between populations in the spatial spreading of the disorder, the influence of environmental factors and cultural traditions on the rate of FMF incidence, and possible selective advantage in carriers of FMF causing gene (MEFV) mutations.

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