Curcumin: the Indian solid gold. Adv Exp Med Biol

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Advances in Experimental Medicine and Biology (Impact Factor: 1.96). 02/2007; 595:1-75. DOI: 10.1007/978-0-387-46401-5_1
Source: PubMed


Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in the Indian subcontinent, not only for health care but also for the preservation of food and as a yellow dye for textiles. Curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as diferuloylmethane was determined in 1910. Since the time of Ayurveda (1900 Bc) numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Extensive research within the last half century has proven that most of these activities, once associated with turmeric, are due to curcumin. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses. These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN). Considering the recent scientific bandwagon that multitargeted therapy is better than monotargeted therapy for most diseases, curcumin can be considered an ideal "Spice for Life".

Download full-text


Available from: Bharat Aggarwal, Apr 15, 2015

Click to see the full-text of:

Article: Curcumin: the Indian solid gold. Adv Exp Med Biol

0 B

See full-text
    • "Curcumin responded to fluoride ion via the formation of a hydrogen bonded complex, which led to significant changes in its optical properties. Sometimes termed as the Indian solid gold [17], Curcumin is most researched for its medicinal properties and consequent applications in drug therapy for cancer and recently even in treatment of Alzheimer's [18]. Some work has also been published with reference to the application of Curcumin in the synthesis of nanoparticles and dye sensitized solar cells [19], [20]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The present work reports a simple fluorescence based tapered fiber optic probe for fluoride ion having a detection range of 2.08 × 10-6 - 2.005×10-4 M. The performance of the tapered probe is evaluated with respect to probes that consist of combinations of bare un-cladded multimode optical fibers. The effect of fluorescence quenching of a natural dye Curcumin in the presence of fluoride ion is used in the implementation of the probes. The probe effectively uses multiple mechanisms for the excitation and collection of fluorescence from the medium enabling higher sensitivity compared to conventional spectrophotometry especially at very low concentrations of fluoride.
    IEEE Sensors Journal 10/2015; 15(10):1-1. DOI:10.1109/JSEN.2015.2445214 · 1.76 Impact Factor
  • Source
    • "Curcumin is responsible for the yellow color of the turmeric. It was first isolated almost two centuries ago and its structure diferuloylmethane was determined in 1910 [33] . Curcumin is known to impact several vital signaling pathways, which affect all the hallmarks of cancer and sensitize tumors to chemotherapeutic agents [2, 34-35] . "
    [Show abstract] [Hide abstract]
    ABSTRACT: Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural compounds, which have shown anti-cancer activity. Natural compounds induce cell cycle arrest, activate intrinsic and extrinsic apoptosis pathways, generate Reactive Oxygen Species (ROS), and down-regulate activated signaling pathways, resulting in inhibition of cell proliferation, progression and metastasis of cancer. Several preclinical studies have suggested that natural compounds can also increase the sensitivity of resistant cancers to available chemotherapy agents. Furthermore, combining FDA approved anti-cancer drugs with natural compounds results in improved efficacy. On the basis of these exciting outcomes of natural compounds against several cancer types, several agents have already advanced to clinical trials. In conclusion, preclinical results and clinical outcomes against cancer suggest promising anticancer efficacy of agents from natural sources.
    Chinese Journal of Natural Medicines 10/2015; 13(10):730-742. DOI:10.1016/S1875-5364(15)30073-X · 1.11 Impact Factor
  • Source
    • "The dose of CUR used in this study was based on previous studies in which curcumin exerted a protective effect against oxidant damage in the liver [19] and kidney [20]. CUR is derived from turmeric (Curcuma longa) as a yellow pigment which is commonly used as a spice, additive, and food colorant [21]. CUR, the most abundant curcuminoid compound in turmeric has various biological properties such as antioxidant [22] [23], antiinflammatory [24] [25], antimicrobial [26] and anticancer activities. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4)-induced nephrotoxicity to evaluate the detailed mechanisms by which CUR exerts its protective action. Thirty male Wistar-Albino rats weighing 250-300g were randomly divided into three groups: administrations of olive oil (control, po), CCl4 (0.5mg/kg in olive oil sc) every other day for 3 weeks, and CCl4 (0.5mg/kg in olive oil sc) plus CUR (200mg/kg) every day for 3 weeks. Administration of CCl4 significantly (p<0.001) increased the levels of renal function test such as creatinine and blood urea nitrogen (BUN). Furthermore, treatment of CCl4 significantly elevated the oxidant status of renal tissues while decreasing its anti-oxidant status (p<0.001). CUR displayed a renal protective effect as evident by significant decrease in inflammation and apoptosis during histopathological examination. The administration of CCl4 resulted in an increase in malondialdehyde (MDA) production due to an increase in membrane lipid peroxidation; however, the administration of CUR attenuated this, probably via its antioxidant and free radical scavenging properties. The finding of our study indicates that CUR may have an important role to play in protecting the kidney from oxidative insult. Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
    Pharmacological reports: PR 06/2015; 67(3). DOI:10.1016/j.pharep.2014.10.021 · 1.93 Impact Factor
Show more