Dissociation between the aversive and pharmacokinetic effects of ethanol in female Fischer and Lewis rats.

Psychopharmacology Laboratory, Department of Psychology, American University, 4400 Massachusetts Avenue, NW, Washington, DC, USA.
Behavioural Brain Research (Impact Factor: 3.39). 09/2007; 182(1):51-6. DOI: 10.1016/j.bbr.2007.05.012
Source: PubMed

ABSTRACT In humans and laboratory animal models, vulnerability to alcohol abuse is influenced by endogenous factors such as genotype. Using the inbred Fischer and Lewis rat strains, we previously reported stronger conditioned taste aversions (CTA) in male Fischer rats that could not be predicted by genotypic differences in alcohol absorption [Roma PG, Flint WW, Higley JD, Riley AL. Assessment of the aversive and rewarding effects of alcohol in Fischer and Lewis rats. Psychopharmacology (Berl) 2006;189:187-99]. The present study made similar assessments in Fischer and Lewis females via four-trial CTA induced by 1 or 1.5 g/kg intraperitoneal (IP) ethanol (n=10-12/strain/dose) as well as measures of blood alcohol concentrations (BAC) at 15, 60 and 180 min post-injection with 1.5 g/kg IP ethanol or saline (n=7-8/strain/dose). Dose-dependent CTAs were produced, but the strains did not differ from each other in these measures; however, BACs in the Lewis females were significantly higher than Fischer at all three time points. As with males of the Fischer and Lewis genotypes, a dissociation between BACs and the aversive effects of alcohol was observed. These data are the first assessments of these particular phenotypes in Fischer and Lewis females, and when considered with the historical data, suggest a Genotype x Sex interaction in the centrally mediated sensitivity to alcohol's aversive effects.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Vulnerability to alcoholism is determined by many factors, including the balance of pleasurable vs. aversive alcohol-induced sensations: pleasurable sensations increase intake, while aversive sensations decrease it. Female sex and adolescent age are associated with lower sensitivity to intake-reducing effects and more rapid development of alcohol abuse. This study assessed voluntary drinking and the aversive effects of alcohol to determine whether these measures are inversely related across the sexes and development. Voluntary drinking of 20 % ethanol in an every-other-day (EOD) availability pattern and the dose-response relationship of ethanol conditioned taste aversion (CTA) were assessed in male and female adolescent and adult rats. CTA was sex specific in adult but not adolescent rats, with adult females exhibiting less aversion. Voluntary ethanol consumption varied according to age and individual differences but was not sex specific. Adolescents initially drank more than adults, exhibited greater day-to-day variation in consumption, were more susceptible to the alcohol deprivation effect, and took longer to establish individual differences in consumption patterns. These results show that the emergence of intake patterns differs between adolescents and adults. Adolescents as a group initiate drinking at high levels but decrease intake as they mature. A subset of adolescents maintained high drinking levels into adulthood. In contrast, most adults consumed at steady, low levels, but a small subset quickly established and maintained high-consumption patterns. Adolescents also showed marked deprivation-induced increases. Sex differences were not observed in EOD drinking during either adolescence or adulthood.
    Psychopharmacology 10/2013; DOI:10.1007/s00213-013-3319-y · 3.99 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A class of exact fast algorithms originally introduced in the signal processing area is provided by the so-called recursive least squares ladder forms. The many nice numerical and structural properties of these algorithms have made them a very powerful alternative in a very large variety of applications. Yet the convergence properties of the algorithms have not received the necessary attention. This paper gives an asymptotic analysis of two particular ladder algorithms, designed for auto-regressive (AR) and auto-regressive-moving-average (ARMA) models. Convergence is studied based on the stability properties of an associated differential equation. The conditions obtained for the convergence of the algorithms parallel those known for prediction error methods and for a particular type of pseudo-linear regression.
    Decision and Control, 1984. The 23rd IEEE Conference on; 01/1985
  • [Show abstract] [Hide abstract]
    ABSTRACT: 24th Congress Meeting of European-College-of-Neuropsychopharmacology Sep 03-07, 2011 , Paris, FRANCE
    European Neuropsychopharmacology 09/2011; 21:S544-S545. DOI:10.1016/S0924-977X(11)70886-0 · 5.40 Impact Factor

Full-text (2 Sources)

Available from
Jun 3, 2014

Pete Roma