Personality and heart disease.

Heart (British Cardiac Society) (Impact Factor: 6.02). 08/2007; 93(7):783-4. DOI: 10.1136/hrt.2006.109355
Source: PubMed


Available from: Gerard J Molloy, Jun 13, 2015
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    ABSTRACT: Tumor necrosis factor-alpha (TNF-alpha) and its soluble receptors 1 (sTNFR1) and 2 (sTNFR2) have been shown to be implicated in the pathogenesis of chronic heart failure (CHF). Ageing is accompanied by increased plasma levels of pro-inflammatory cytokines. We hypothesized that Type D personality (joint tendency to experience negative emotions and to inhibit self-expression) and age may have similar pro-inflammatory effects in the context of CHF. Participants in this study were 130 consecutive outpatients with CHF (76% men); there were 70 relatively younger (<or=59 years) and 60 relatively older (>or=60 years) patients. They all completed the 14-item Type D Scale (DS14); 43 patients (33%) had a Type D personality. A multivariate model of cytokine levels indicated an independent overall effect of both older age [F(1,128)=9.11, p=.003] and Type D personality [F(1,128)=8.28, p=.005]. Stratifying patients in age/personality subgroups showed that younger non-Type D patients had the lowest and older Type D patients the highest sTNFR1 and sTNFR2 levels (986+/-318 vs 1661+/-1128 pg/ml and 1838+/-777 vs 2823+/-1439 pg/ml, p<.0001). Importantly, the mean sTNFR1 level in younger Type D patients (1359+/-660 pg/ml) was equivalent to that in older non-Type D patients (1360+/-440 pg/ml, p=.99) who were on average 18 years older. Younger Type D and older non-Type D patients also had similar sTNFR2 levels (2406+/-1329 vs 2448+/-812 pg/ml, p=.88). Only older Type D patients had a higher mean TNF-alpha level as compared to patients who were younger or who were not Type D (5.4+/-2.9 vs 3.9+/-2.4 pg/ml, p=.008). A logistic regression model including sex, severity of CHF, systolic heart failure and ischemic etiology indicated that the combined risk category of older age or Type D was independently associated with substantially increased sTNFR1 and sTNFR2 levels. Hence, Type D personality was associated with increased TNF-alpha activity. This disease-promoting effect of Type D matched the pro-inflammatory effect of ageing.
    Brain Behavior and Immunity 07/2008; 22(5):736-43. DOI:10.1016/j.bbi.2007.10.015 · 6.13 Impact Factor
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    Revista cubana de medicina 03/2011; 50(1):83-93.
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    ABSTRACT: Prospective studies have linked negative affect with hypertension, cardiovascular disease, and mortality. This study aims to identify if cardiovascular activity in day-to-day settings is related to affect levels as assessed using the Day Reconstruction Method (Kahneman, Krueger, Schkade, Schwarz, & Stone, 2004). 186 people underwent baseline physiological testing and were monitored naturalistically for an entire day. Multilevel models were the principal analyses used. We utilized an online day reconstruction survey to produce a continuous account of affect, social interactions, and activity patterns during waking hours. Ambulatory heart rate (HR) was assessed during the same period. Personality, health behavior, consumption, self-reported activity, and baseline physiological characteristics were assessed to isolate the relationships between affect and HR. Negative affect predicted an elevated ambulatory HR and tiredness predicted a lower HR. Associations between negative affectivity and increased cardiovascular reactivity were maintained after taking account of baseline physiological factors, health behavior, and personality. Negative affect in everyday life is a reliable predictor of HR. Combining day reconstruction with psychophysiological and environmental monitoring is a minimally invasive method with promising interdisciplinary relevance.
    Health Psychology 03/2010; 29(2):186-95. DOI:10.1037/a0017626 · 3.95 Impact Factor