Hypersexuality After Right Pallidotomy for Parkinson’s Disease
ABSTRACT The authors describe hypersexuality following atypical right pallidotomy for intractable Parkinson's Disease (PD). This patient and literature review suggest important roles for the pallidum in sexual behavior and dopamine in sexual arousal.
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- "Marlowe et al. 1975; Ghika-Schmid et al. 1995). Hypersexuality and paraphilias have also been observed in conjunction with damage to subcortical structures such as the thalamus or hypothalamus (Cummings and Mendez 1984; Miller et al. 1986; Absher et al. 2000), the septum (Miller et al. 1986; Gorman and Cummings 1992), the hippocampus, (Mendez et al. 2000; Casanova et al. 2002), and the basal ganglia (globus pallidus; Mendez et al. 2004; striatum in Huntington disease; e.g. Dewhurst et al. 1970). "
ABSTRACT: Current neurological hypotheses of paraphilia posit that sexual deviance is associated with frontal and/or temporal lobe damage. This broad conception is based on few investigations, however, and the first goal of this study was to review the existing data derived from neuropsychiatry, neuroimaging and neuropsychology. It is concluded that although fronto-temporal dysfunctions are sporadically reported among sexual offenders, the evidence is scarce and it might not be specific to this type of offending. The second objective of this investigation was to gather preliminary neuropsychological data with more homogeneous subgroups of sexual offenders. A profile of lower-order executive dysfunctions (e.g. sustained attention and inhibition) and verbal deficits with intact or good capacities for higher-order executive functioning (e.g. reasoning and cognitive flexibility) and visuo-spatial processing was preferentially found among sexual offenders, suggesting basal fronto-temporal anomalies. Importantly, pedophiles were more consistently and severely impaired than rapists of adults. However, this basal fronto-temporal profile is not characteristic of sexual deviance, as it is also found in association with delinquency and criminality in general. Future neuropsychological and brain imaging studies should consider subgroups of sexual offenders and recruit non-sexual violent persons and non-violent individuals in order to disentangle the complex relations between brain anomalies and sexual deviance.Sexual Abuse A Journal of Research and Treatment 07/2007; 19(2):155-73. DOI:10.1007/s11194-007-9045-4 · 2.28 Impact Factor
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ABSTRACT: Compulsive sexual behavior, otherwise known as sexual addiction, is an emerging psychiatric disorder that has significant medical and psychiatric consequences. Until recently, very little empirical data existed to explain the biological, psychological, and social risk factors that contribute to this condition. In addition, clinical issues, such as the natural course and best practices on treating sexual addictions, have not been formalized. Despite this absence, the number of patients and communities requesting assistance with this problem remains significant. This article will review the clinical features of compulsive sexual behavior and will summarize the current evidence for psychological and pharmacological treatment.Psychiatry 11/2006; 3(11):51-8.
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ABSTRACT: We review the human literature examining the effects of neurological insult on human sexual behaviour. We provide a synthesis of the findings to date, and identify key brain regions associated with specific aspects of human sexual behaviour. These include subcortical and cortical regions, with the mesial temporal lobe and the amygdala in particular being a crucial structure in the mediation of human sexual drive.Journal of neurology, neurosurgery, and psychiatry 11/2007; 78(10):1042-9. DOI:10.1136/jnnp.2006.107193 · 6.81 Impact Factor