Bactericidal silver ion delivery into hydrophobic coatings with surfactants

School of Engineering Technology, Eastern Michigan University, Ypsilanti, MI 48197, USA.
Journal of Industrial Microbiology and Biotechnology (Impact Factor: 2.44). 09/2007; 34(8):571-5. DOI: 10.1007/s10295-007-0228-2
Source: PubMed


A much studied oil-soluble surfactant, bis[2-ethylhexyl]sulfosuccinate, sodium salt, was ion exchanged into the silver ion form and dissolved into microemulsions of immiscible polyurethane step monomers. Coating and curing of these microemulsions produced polyurethane coatings that exhibit bactericidal activity against representative Gram negative bacteria. After 24 h exposure, 0.006-0.012% weight Ag relative to coating weight (0.0013-0.0025 micromol Ag/cm2) results in the three-log reduction in Escherichia coli. A slightly higher level of 0.031% weight Ag relative to coating weight (0.006 micromol Ag/cm2) killed all of the E. coli after 12 h exposure. Similar results were obtained for Pseudomonas aeruginosa. Since the double-tail surfactant anion promotes reverse micelle formation in many different kinds of oils and solvents, it appears an excellent vector for incorporating low and effective amounts of silver ion into many industrial, hospital, and household coating formulations.

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    • "Another explanation was done based on intervention of silver in DNA replication and ion transportation across the respiratory chain (Feng et al., 2000; Texter, Ziemer, Rhoades, & Clemans, 2007), which eventually leads to cell death (Martínez-Abad et al., 2012). Although the mechanism remains the subject of debate (Dibrov, Dzioba, Gosink, & Häse, 2002 and Texter et al., 2007), the antimicrobial of silver is explained by three mechanisms: (a) interference with electron transport, which blocks energy production; (b) binding to the DNA; and (c) interaction with the cell membrane (Tilton & Rosenberg, 1978). DNA was shown to be denaturized by silver (+ 1) ions by forming a complex at bases, leading to denaturation by displacing hydrogen bonds between adjacent nitrogen of purines and pyrimidines and finally to prevention of DNA replication. "
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    • "Metallic nanoparticles (NP) are finding increasing applications in electrochemistry, catalysis, sensor, optoelectronics , biotechnology and other emerging research fields [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Apart from this, Ag NP also exhibit various biological activities including antifungal and antibacterial properties [12] [13] [14] [15]. In general, the metallic NP tend to aggregate, and it is quite challenging to keep them stable in dispersion. "
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