Article

Endometrioid adenocarcinoma with a functioning stroma.

Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Yamagata, Japan.
Journal of Obstetrics and Gynaecology Research (impact factor: 0.94). 07/2007; 33(3):381-3. DOI:10.1111/j.1447-0756.2007.00541.x
Source: PubMed

ABSTRACT A case of a 70-year-old woman with endometrioid adenocarcinoma of the ovary with functioning stroma is presented. The symptom was postmenopausal bleeding. The preoperative level of serum estradiol was as high as 162.4 pg/mL, and serum gonadotropin levels were suppressed. The endometrial tissue showed hyperplastic changes. The surgical specimens consisted of a multilocular cystic ovarian tumor of 95 mm in diameter and an enlarged uterus. Histologically, the tumor was composed of proliferating, atypical, columnar cancer cells resembling early secretory endometrial cells, and condensation of plumed stromal cells resembling theca lutein cells. The diagnosis of endometrial adenocarcinoma of the ovary with functioning stroma was made. After surgery, the serum levels of estradiol decreased and of follicle-stimulating hormone increased. Almost all types of ovarian tumor have been reported to be associated with endocrine abnormalities. Mucinous epithelial ovarian tumors most commonly present with estrogenic stroma, although the frequency of endometrioid adenocarcinoma with functioning stroma is very low. Here, a rare case with the patient's clinical course and histopathologic findings is reported.

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  • Article: Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.
    Tomomi Katoh, Masanori Yasuda, Kosei Hasegawa, Eito Kozawa, Jun-Ichi Maniwa, Hironobu Sasano
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    ABSTRACT: The 4 present cases with endometrioid adenocarcinoma (EMA) of the ovary were characterized by estrogen overproduction and resemblance to sex cord-stromal tumor (SCST). The patients were all postmenopausal, at ages ranging from 60 to 79 years (av. 67.5), who complained of abdominal discomfort or distention and also atypical genital bleeding. Cytologically, maturation of the cervicovaginal squamous epithelium and active endometrial proliferation were detected. The serum estrogen (estradiol, E2) value was preoperatively found to be elevated, ranging from 48.7 to 83.0 pg/mL (av. 58.4). In contrast, follicle stimulating hormone was suppressed to below the normal value. MR imaging diagnoses included SCSTs such as granulosa cell tumor or thecoma for 3 cases because of predominantly solid growth, and epithelial malignancy for one case because of cystic and solid structure. Grossly, the solid part of 3 cases was homogeneously yellow in color. Histologically, varying amounts of tumor components were arranged in solid nests, hollow tubules, cord-like strands and cribriform-like nests in addition to the conventional EMA histology. In summary, postmenopausal ovarian solid tumors with the estrogenic manifestations tend to be preoperatively diagnosed as SCST. Due to this, in the histological diagnosis, this variant of ovarian EMA may be challenging and misdiagnosed as SCST because of its wide range in morphology. Virtual slides http://www.diagnosticpathology.diagnomx.eu/vs/6096841358065394.
    Diagnostic Pathology 11/2012; 7(1):164. · 1.64 Impact Factor
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Keywords

70-year-old woman
 
atypical
 
columnar cancer cells
 
endocrine abnormalities
 
endometrial adenocarcinoma
 
endometrial tissue
 
endometrioid adenocarcinoma
 
enlarged uterus
 
estrogenic stroma
 
follicle-stimulating hormone
 
Mucinous epithelial ovarian tumors
 
multilocular cystic ovarian tumor
 
ovarian tumor
 
patient's clinical course
 
plumed stromal cells
 
rare case
 
secretory endometrial cells
 
serum gonadotropin levels
 
surgical specimens
 
theca lutein cells