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    ABSTRACT: Objective: The metabolic syndrome (MetS) has become one of the major public-health challenges worldwide. Early identification of metabolic complications consist an essential target for youth public health. We aimed to evaluate the prevalence of MetS and its components among overweight and obese adolescents. Methods: This cross-sectional study concerned 51 overweight and obese adolescents. Anthropometric assessments, blood pressure measurement and biochemical assessment were done. MetS was defined according to the International Diabetes Federation (IDF) criteria. All data were collected during one academic school year in 2012 and 2013. Results: The prevalence of the MetS was 21.6%. There was no gender difference in prevalence of MetS (P=0.09). Obese subjects had the highest proportion of MetS than overweight (25% vs. 15.8%; p=0.04). 35.3% of subjects had at least two abnormalities of MetS. Abdominal obesity was the most common individual component of the MetS (91.3 %) followed by low HDL cholesterol (58.8%). Body mass index (BMI), Waist circumference (WC), Waist to hip ratio (WRH) and Neck circumference (NC) had partial positive correlation with Blood pressure (BP), and Triglyceride. Similarly, (BP), Triglyceride and HDL cholesterol were significantly higher in subjects with metabolic syndrome than that of subjects without metabolic syndrome (p < 0.05). Conclusion: MetS is prevalent in our young population in Sfax City. The results of this study will help in planning to control these problems in the future. So we suggest screening programs for secondary school adolescent to control obesity and MetS in Tunisia.
    03/2015; 3(1):1-6. DOI:10.12691/ijcn-3-1-1
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    ABSTRACT: With the rise in childhood obesity, type 2 diabetes mellitus (T2DM) has been recognized to occur in adolescents with increasing frequency. Although much is known about T2DM in adults, few studies have examined the treatment and complications of T2DM in youth. The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study was designed to evaluate the efficacy of various treatments and provided a unique opportunity to study the disease progression and appearance of complications in a pediatric cohort with recent onset of the disease. In the TODAY study, hypertension was present in 11.6% of the population at baseline and increased to 33.8% by the end of the study. Prevalence of high-risk LDL-cholesterol rose from 4.5% at baseline to 10.7% at the end of the study. Microalbuminuria was found in 6.3% of the cohort at baseline and increased to 16.6%. Retinopathy was not assessed upon entry into TODAY, but was present in 13.9% of the TODAY cohort at the end of the study. Experience to date indicates that these complications and comorbidities are similar to those seen in adults, but occur on an accelerated timeline. The early manifestation of diabetes complications in youth-onset T2DM suggests that this group will be burdened with the tangible consequences of cardiovascular disease, nephropathy, and retinopathy in the third and fourth decades of life. It is hoped that through an early, aggressive approach to treatment and prevention, we may be able to curb the onset and progression of these potentially devastating outcomes. Copyright © 2014 Elsevier Inc. All rights reserved.
    Journal of Diabetes and its Complications 10/2014; 29(2). DOI:10.1016/j.jdiacomp.2014.10.009 · 1.93 Impact Factor
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    ABSTRACT: Background Growth-curves are an important tool for evaluating the anthropometric development in pediatrics. The different growth-curves available are based in different populations, what leads to different cut-offs. Pediatric obesity tracks into adulthood and is associated with increased cardiovascular risk. The accurate assessment of a child nutritional status using growth-curves can indicate individuals that are either obese or in risk of becoming obese, allowing an early intervention. Moreover, the association between the data obtained from growth-curves with specific metabolic risk factors further highlights the importance of these charts. This study aimed to evaluate the associations between body mass index z-score (BMIzsc), determined using the growth-curves from the Centre for Disease Control and Prevention (CDC) and from the World Health Organization (WHO), with cardiovascular risk factors, represented here by metabolic syndrome (MS) and insulin resistance (IR) related parameters. Findings The study involved 246 obese adolescents (10–18 years, 122 females). MS was defined according to the International Diabetes Federation. IR was considered for HOMA-IR greater than 2.5. No difference between both BMIzsc in identifying MS was noticeable by a ROC analysis. For both indexes the area-under-the-curve increased for older groups, particularly for males. CDC-BMIzsc was the best predictor of MS by logistic regression when all population was considered, however MS was better predicted by WHO-BMIzsc for females and by CDC-BMIzsc for males. Younger girls and older boys were in increased risk for MS. Similar results were obtained for IR. Conclusions A significant difference between the two BMIzsc regarding their association with MS and IR was not clear, being these associations weaker in younger individuals.
    Diabetology and Metabolic Syndrome 04/2015; 7(32). DOI:10.1186/s13098-015-0022-7 · 2.50 Impact Factor

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Jun 3, 2014