Muscle-strengthening activity and its association with insulin sensitivity.
ABSTRACT Muscle-strengthening activities (MSAs) may increase insulin sensitivity, thereby reducing the risk of diabetes. The purpose of this study was to assess the relationship between MSAs and insulin sensitivity among American adults.
We analyzed data on 4,504 adults without diabetes, aged 20-79 years, who participated in the National Health and Nutrition Examination Survey 1999-2004 and had information on MSAs. Self-reported frequency (times/week) of MSAs was grouped as low (<1), moderate (1-2.9), or high (>or=3). Insulin sensitivity was measured by the fasting quantitative insulin sensitivity check index x 100 (QUICKI).
After adjustment for age, race/ethnicity, physical activity other than MSAs, BMI, smoking, alcohol consumption, and daily total caloric intake, the mean values for QUICKI by low, moderate, and high MSA were 33.6, 33.9, and 34.2, respectively (P for linear trend = 0.008) for men and 34.2, 34.6, 34.6, respectively (P for linear trend = 0.009) for women. Mean fasting insulin (picomols per liter) concentrations were 75.0, 68.9, and 65.9, respectively (P for linear trend = 0.017) for men and 66.9, 63.3, 61.2, respectively (P for linear trend = 0.007) for women. There were no significant differences across MSA groups for fasting glucose among men or women.
MSA is independently associated with higher insulin sensitivity among U.S. adults. Efforts to increase MSA may be a realistic, feasible, and effective method of reducing insulin resistance among the U.S. population.
- SourceAvailable from: May A Beydoun[Show abstract] [Hide abstract]
ABSTRACT: The associations between nutritional biomarkers and measures of sleep quantity and quality remain unclear.PLoS ONE 01/2014; 9(8):e103490. · 3.53 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Regular physical activity elicits multiple health benefits in the prevention and management of chronic diseases. We examined the mortality risks associated with levels of leisure-time aerobic physical activity and muscle-strengthening activity based on the 2008 Physical Activity Guidelines for Americans among US adults. We analysed data from the 1999 to 2004 National Health and Nutrition Examination Survey with linked mortality data obtained through 2006. Cox proportional HRs with 95% CIs were estimated to assess risks for all-causes and cardiovascular disease (CVD) mortality associated with aerobic physical activity and muscle-strengthening activity. Of 10 535 participants, 665 died (233 deaths from CVD) during an average of 4.8-year follow-up. Compared with participants who were physically inactive, the adjusted HR for all-cause mortality was 0.64 (95% CI 0.52 to 0.79) among those who were physically active (engaging in ≥150 min/week of the equivalent moderate-intensity physical activity) and 0.72 (95% CI 0.54 to 0.97) among those who were insufficiently active (engaging in >0 to <150 min/week of the equivalent moderate-intensity physical activity). The adjusted HR for CVD mortality was 0.57 (95% CI 0.34 to 0.97) among participants who were insufficiently active and 0.69 (95% CI 0.43 to 1.12) among those who were physically active. Among adults who were insufficiently active, the adjusted HR for all-cause mortality was 44% lower by engaging in muscle-strengthening activity ≥2 times/week. Engaging in aerobic physical activity ranging from insufficient activity to meeting the 2008 Guidelines reduces the risk of premature mortality among US adults. Engaging in muscle-strengthening activity ≥2 times/week may provide additional benefits among insufficiently active adults.British journal of sports medicine 10/2013; · 3.67 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Obesity may attenuate metabolic health improvements following lifestyle interventions. However, the effect of adiposity on insulin action following resistance exercise in young non-diabetic women is unknown. The purpose of this study was to test the hypothesis that adiposity attenuates improvements in insulin sensitivity and glucose-stimulated insulin secretion (INS0-60/GLC0-60) after both acute resistance exercise (ARE) and progressive training (PRT). Twenty-six young non-diabetic women (21.2 ± 0.7 years) were randomly assigned to control (C; n = 7; BF 40.1 ± 2.1 %) or exercise groups: normal body fat (NBF; n = 8; BF 29.9 ± 2.3 %) and high body fat (HBF; n = 12; BF 48.2 ± 1.4 %). Acute whole-body exercises were performed at 60 % of 1-RM for three sets of 8-12 repetitions, and PRT was performed 3 days/week for 7 weeks. A 75 g OGTT was conducted before and after ARE and PRT to estimate insulin sensitivity (Matsuda index) and INS0-60/GLC0-60. Insulin area under the curve (AUC) was calculated using the trapezoidal model. ARE had no statistical effect on insulin action across groups. Strength and fat-free mass (via DXA) increased after PRT in both NBF and HBF (p < 0.05), but only HBF women decreased BF (p < 0.01). HBF women were less insulin sensitive at baseline compared to NBF women (p < 0.05). Insulin sensitivity increased 95 % and INS0-60/GLC0-60 decreased 32 % following PRT in NBF, but not HBF or C (p < 0.05). After training, enhanced insulin sensitivity was inversely related to decreased INS0-60/GLC0-60 (r = -0.71, p < 0.001), fasting insulin (r = -0.71, p < 0.001), and insulin AUC (r = -0.85, p < 0.001). Seven weeks of PRT increases insulin sensitivity and reduces glucose-stimulated insulin secretion in NBF, but not HBF women. Obesity attenuates exercise-induced improvements in glucose regulation in young non-diabetic women.Arbeitsphysiologie 09/2013; · 2.66 Impact Factor